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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
DHT and estradiol regulate fat in different areas of the body
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<blockquote data-quote="Nelson Vergel" data-source="post: 192366" data-attributes="member: 3"><p>Very interesting and it agrees with this study:</p><p></p><p></p><p><a href="https://www.medpagetoday.com/Endocrinology/GeneralEndocrinology/47530" target="_blank"><strong>Estradiol May Prevent Fat Accumulation</strong></a></p><p></p><p></p><p>At least in female rodents...</p><p></p><p></p><p>"administration of supplemental doses of estradiol appeared to prevent fat accumulation and overcome leptin resistance in ovarian-intact and ovariectomized female high-fat-diet mice, they wrote online in the journal <a href="http://press.endocrine.org/journal/endo" target="_blank"><em>Endocrinology.</em></a></p><p>But response to estradiol treatment in the high-fat-diet animals depended on endogenous estrogenic status, they cautioned.</p><p>"When estradiol (E2) was cyclically administered to ovarian-intact HFD-fed mice for 12 weeks, the animals gained significantly less weight than ovarian-intact vehicle controls (<em>P</em><0.01)," the researchers wrote. "This difference was mainly due to reduced caloric intake and not to an increase in energy expenditure or locomotor activity."</p><p></p><p>This study shows what happens to sexual function and body composition at different blood levels of testosterone and/or estradiol.</p><p></p><p></p><p><strong>Gonadal Steroids and Body Composition, Strength, and Sexual Function in Men</strong></p><p></p><p>N Engl J Med. Sep 12, 2013; 369(11): 1011;1022.</p><p></p><p>All participants received goserelin acetate (Zoladex, AstraZeneca), at a dose of 3.6 mg subcutaneously at weeks 0, 4, 8, and 12, to suppress endogenous gonadal steroids. Participants were then randomly assigned to receive 0 g (placebo), 1.25 g, 2.5 g, 5 g, or 10 g of a topical 1% testosterone gel (AndroGel, Abbott Laboratories) daily for 16 weeks. Participants in cohort 2 also received anastrozole (Arimidex, AstraZeneca) at a dose of 1 mg daily to block the aromatization of testosterone to estrogen. Participants were unaware of the study-group assignments.</p><p>Participants were seen every 4 weeks. At each visit, fasting blood samples were obtained to measure gonadal steroid levels, and questionnaires were administered to assess physical function, health status, vitality, and sexual function. At baseline and week 16, body fat and lean mass were assessed by means of dual-energy x-ray absorptiometry (DXA); subcutaneous- and intraabdominal-fat areas and thigh-muscle area were measured by means of computed tomography (CT); and lower-extremity strength was determined by means of a leg press. Data on bone homeostasis (bone-turnover markers and bone mineral density), risk factors for cardiovascular disease (blood pressure, lipids, and insulin sensitivity), and levels of leptin and prostate-specific antigen were also collected but are not included in the present report.</p><p></p><p>"...<strong>we found that lean mass, muscle size, and strength are regulated by androgens (testosterone); fat accumulation is primarily a consequence of estrogen deficiency (low estradiol); and sexual function is regulated by both androgens and estrogens. </strong>Delineation of the degrees of hypogonadism at which undesirable consequences develop and of the relative roles of androgens (testosterone) and estrogens in each outcome should facilitate the development of more rational approaches to the diagnosis and treatment of hypogonadism in men."</p><p></p><p></p><p></p><p>Source: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142768/" target="_blank">Gonadal Steroids and Body Composition, Strength, and Sexual Function in Men</a></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 192366, member: 3"] Very interesting and it agrees with this study: [URL='https://www.medpagetoday.com/Endocrinology/GeneralEndocrinology/47530'][B]Estradiol May Prevent Fat Accumulation[/B][/URL] At least in female rodents... "administration of supplemental doses of estradiol appeared to prevent fat accumulation and overcome leptin resistance in ovarian-intact and ovariectomized female high-fat-diet mice, they wrote online in the journal [URL='http://press.endocrine.org/journal/endo'][I]Endocrinology.[/I][/URL] But response to estradiol treatment in the high-fat-diet animals depended on endogenous estrogenic status, they cautioned. "When estradiol (E2) was cyclically administered to ovarian-intact HFD-fed mice for 12 weeks, the animals gained significantly less weight than ovarian-intact vehicle controls ([I]P[/I]<0.01)," the researchers wrote. "This difference was mainly due to reduced caloric intake and not to an increase in energy expenditure or locomotor activity." This study shows what happens to sexual function and body composition at different blood levels of testosterone and/or estradiol. [B]Gonadal Steroids and Body Composition, Strength, and Sexual Function in Men[/B] N Engl J Med. Sep 12, 2013; 369(11): 1011;1022. All participants received goserelin acetate (Zoladex, AstraZeneca), at a dose of 3.6 mg subcutaneously at weeks 0, 4, 8, and 12, to suppress endogenous gonadal steroids. Participants were then randomly assigned to receive 0 g (placebo), 1.25 g, 2.5 g, 5 g, or 10 g of a topical 1% testosterone gel (AndroGel, Abbott Laboratories) daily for 16 weeks. Participants in cohort 2 also received anastrozole (Arimidex, AstraZeneca) at a dose of 1 mg daily to block the aromatization of testosterone to estrogen. Participants were unaware of the study-group assignments. Participants were seen every 4 weeks. At each visit, fasting blood samples were obtained to measure gonadal steroid levels, and questionnaires were administered to assess physical function, health status, vitality, and sexual function. At baseline and week 16, body fat and lean mass were assessed by means of dual-energy x-ray absorptiometry (DXA); subcutaneous- and intraabdominal-fat areas and thigh-muscle area were measured by means of computed tomography (CT); and lower-extremity strength was determined by means of a leg press. Data on bone homeostasis (bone-turnover markers and bone mineral density), risk factors for cardiovascular disease (blood pressure, lipids, and insulin sensitivity), and levels of leptin and prostate-specific antigen were also collected but are not included in the present report. "...[B]we found that lean mass, muscle size, and strength are regulated by androgens (testosterone); fat accumulation is primarily a consequence of estrogen deficiency (low estradiol); and sexual function is regulated by both androgens and estrogens. [/B]Delineation of the degrees of hypogonadism at which undesirable consequences develop and of the relative roles of androgens (testosterone) and estrogens in each outcome should facilitate the development of more rational approaches to the diagnosis and treatment of hypogonadism in men." Source: [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142768/']Gonadal Steroids and Body Composition, Strength, and Sexual Function in Men[/URL] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
DHT and estradiol regulate fat in different areas of the body
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