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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
DHN vs DHT?
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<blockquote data-quote="Cataceous" data-source="post: 178236" data-attributes="member: 38109"><p>The first part, increasing DHT, may be pretty straightforward. Scrotal cream is putting a very high concentration of testosterone in contact with dermal 5-alpha reductase. A relatively low concentration of nandrolone and DHN should have minimal influence on DHT creation under these circumstances. In other words, it would take very high doses of nandrolone to make the concentration high enough to seriously compete with the transdermal testosterone and reduce DHT formation.</p><p></p><p>The question of whether DHN can interfere with the benefits of higher DHT is more complicated. First, can you identify what causes the benefits of higher DHT? Is it receptor binding? If so, androgen receptor, estrogen receptor, SHBG, other? Does aromatase inhibition play a role? Any other mechanisms? Once that's known then you have to determine how DHN might affect these. With receptors we'd consider the relative binding affinities of DHT and DHN, and then explore the further question of whether or not you get different effects depending on which androgen binds to the receptor. In the end there might be enough fodder here for someone's doctoral thesis. A quick-and-dirty answer might be possible if you could demonstrate that DHN concentrations are relatively low, though even that requires some digging...</p></blockquote><p></p>
[QUOTE="Cataceous, post: 178236, member: 38109"] The first part, increasing DHT, may be pretty straightforward. Scrotal cream is putting a very high concentration of testosterone in contact with dermal 5-alpha reductase. A relatively low concentration of nandrolone and DHN should have minimal influence on DHT creation under these circumstances. In other words, it would take very high doses of nandrolone to make the concentration high enough to seriously compete with the transdermal testosterone and reduce DHT formation. The question of whether DHN can interfere with the benefits of higher DHT is more complicated. First, can you identify what causes the benefits of higher DHT? Is it receptor binding? If so, androgen receptor, estrogen receptor, SHBG, other? Does aromatase inhibition play a role? Any other mechanisms? Once that's known then you have to determine how DHN might affect these. With receptors we'd consider the relative binding affinities of DHT and DHN, and then explore the further question of whether or not you get different effects depending on which androgen binds to the receptor. In the end there might be enough fodder here for someone's doctoral thesis. A quick-and-dirty answer might be possible if you could demonstrate that DHN concentrations are relatively low, though even that requires some digging... [/QUOTE]
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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
DHN vs DHT?
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