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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
DHEA Supplementation
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<blockquote data-quote="Nelson Vergel" data-source="post: 255083" data-attributes="member: 3"><p>DHEA and DHEAS are converted into several active metabolites, including androstenedione, testosterone, estrone, estradiol, and estriol (Figure 1). The elimination half-life of DHEA is 15-38 minutes, whereas the half-life of DHEAS is 7-22 hours.</p><p></p><p>[URL unfurl="true"]https://www.medscape.com/viewarticle/406925_4#:~:text=DHEA%20and%20DHEAS%20are%20converted,DHEAS%20is%207%2D22%20hours.[/URL]</p><p></p><p>The concept of reaching steady state in pharmacokinetics refers to the point at which the rate of drug administration equals the rate of elimination, resulting in a constant concentration of the drug in the body [3]. The rule of thumb is that steady state is achieved after approximately five half-lives [3]. However, it's important to note that the attainment of steady state can vary depending on the specific drug and individual factors.</p><p></p><p>So, let's pick steady state of DHEA-S (the actual parameter measured in blood tests) of around 11 hours. </p><p></p><p>Approximate (not fully accurate) steady state: 11x5= 55 hours</p><p></p><p>I would wait at least 3 days and test after 3 hours of taking the last dose.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 255083, member: 3"] DHEA and DHEAS are converted into several active metabolites, including androstenedione, testosterone, estrone, estradiol, and estriol (Figure 1). The elimination half-life of DHEA is 15-38 minutes, whereas the half-life of DHEAS is 7-22 hours. [URL unfurl="true"]https://www.medscape.com/viewarticle/406925_4#:~:text=DHEA%20and%20DHEAS%20are%20converted,DHEAS%20is%207%2D22%20hours.[/URL] The concept of reaching steady state in pharmacokinetics refers to the point at which the rate of drug administration equals the rate of elimination, resulting in a constant concentration of the drug in the body [3]. The rule of thumb is that steady state is achieved after approximately five half-lives [3]. However, it's important to note that the attainment of steady state can vary depending on the specific drug and individual factors. So, let's pick steady state of DHEA-S (the actual parameter measured in blood tests) of around 11 hours. Approximate (not fully accurate) steady state: 11x5= 55 hours I would wait at least 3 days and test after 3 hours of taking the last dose. [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
DHEA Supplementation
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