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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Determining optimal Free T value
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<blockquote data-quote="madman" data-source="post: 153759" data-attributes="member: 13851"><p>What is the problem here?</p><p></p><p>People need to understand the newer research regarding SHBG:T binding and the impact it has on FT levels.</p><p></p><p>Equilibrium Dialysis is the gold standard when it comes to testing FT.</p><p></p><p>Unless one is testing FT using Equilibrium Dialysis or Ultrafiltration or using the newer calculated TruT method (which has been shown to be on par with results obtained by Equilibrium Dialysis).....than you truly have no idea where your FT levels sit.</p><p></p><p>It has been shown over and over that the direct immunoassay (which most rely on) is inaccurate let alone no longer recommended by the Endocrine Society.</p><p></p><p>Many also use the (cFTV) Vermeulen which has been shown to grossly underestimate FT levels.</p><p></p><p>If you want to go on and use the other inferior testing methods so be it if it floats your boat <strong><span style="color: rgb(184, 49, 47)">@VinceCarter</span></strong>!</p><p></p><p>LOL.....unfortunately the cut/paste is needed to drive the important points home in those with the thick headed noggins.</p><p></p><p>Again we can all just sit here and say numbers are just numbers and how you feel overall is what truly matters but the simple fact of the matter is that not only is lab work critical to see how said protocol (dose of T/injection frequency) effects ones TT/FT/e2/DHT levels and overall blood markers but what needs to be stressed is using accurate testing methods to truly know where your levels sit as it can make or break a protocol and save many grief in the long run.</p><p></p><p>You very well know that many are running FT levels much higher than they think (due to relying on inaccurate testing methods) let alone need.</p><p></p><p>Of course treating symptoms is what truly matters but one still needs to know where hormone levels sit on such protocol as if we just base it off the "I feel best" nonsense than many men will end up running higher TT/FT (as in well over the reference range) levels than they truly need.</p><p></p><p>One can easily end up saying I feel best on 200 mg/week.....than it becomes I feel best on 300mg/week and so on.....we are on trt here.....replacement doses of testosterone.....most running these higher doses as in 250+mg/week are claiming trt when in fact their TT/FT levels are well into the supra-physiological range.</p><p></p><p>If one chooses to run such high levels on trt so be it......but the truth of the matter is most would never need levels this high to benefit from testosterone replacement therapy.</p><p></p><p>To make matters worse if people on here took the time to understand the newer research regarding SHBG:T binding than they would understand that even if one has higher SHBG very high TT levels as once thought are not needed to achieve a healthy FT level.</p><p></p><p>Think of how many men are running very high TT thinking that there FT is at a healthy level when in fact it is a lot higher than they think due to relying on piss poor FT testing methods.....all this can be resolved by simply using the newer calculated TruT method which uses a model which is based off the newer understanding of SHBG:T binding.</p></blockquote><p></p>
[QUOTE="madman, post: 153759, member: 13851"] What is the problem here? People need to understand the newer research regarding SHBG:T binding and the impact it has on FT levels. Equilibrium Dialysis is the gold standard when it comes to testing FT. Unless one is testing FT using Equilibrium Dialysis or Ultrafiltration or using the newer calculated TruT method (which has been shown to be on par with results obtained by Equilibrium Dialysis).....than you truly have no idea where your FT levels sit. It has been shown over and over that the direct immunoassay (which most rely on) is inaccurate let alone no longer recommended by the Endocrine Society. Many also use the (cFTV) Vermeulen which has been shown to grossly underestimate FT levels. If you want to go on and use the other inferior testing methods so be it if it floats your boat [B][COLOR=rgb(184, 49, 47)]@VinceCarter[/COLOR][/B]! LOL.....unfortunately the cut/paste is needed to drive the important points home in those with the thick headed noggins. Again we can all just sit here and say numbers are just numbers and how you feel overall is what truly matters but the simple fact of the matter is that not only is lab work critical to see how said protocol (dose of T/injection frequency) effects ones TT/FT/e2/DHT levels and overall blood markers but what needs to be stressed is using accurate testing methods to truly know where your levels sit as it can make or break a protocol and save many grief in the long run. You very well know that many are running FT levels much higher than they think (due to relying on inaccurate testing methods) let alone need. Of course treating symptoms is what truly matters but one still needs to know where hormone levels sit on such protocol as if we just base it off the "I feel best" nonsense than many men will end up running higher TT/FT (as in well over the reference range) levels than they truly need. One can easily end up saying I feel best on 200 mg/week.....than it becomes I feel best on 300mg/week and so on.....we are on trt here.....replacement doses of testosterone.....most running these higher doses as in 250+mg/week are claiming trt when in fact their TT/FT levels are well into the supra-physiological range. If one chooses to run such high levels on trt so be it......but the truth of the matter is most would never need levels this high to benefit from testosterone replacement therapy. To make matters worse if people on here took the time to understand the newer research regarding SHBG:T binding than they would understand that even if one has higher SHBG very high TT levels as once thought are not needed to achieve a healthy FT level. Think of how many men are running very high TT thinking that there FT is at a healthy level when in fact it is a lot higher than they think due to relying on piss poor FT testing methods.....all this can be resolved by simply using the newer calculated TruT method which uses a model which is based off the newer understanding of SHBG:T binding. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Determining optimal Free T value
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