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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Determining optimal Free T value
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<blockquote data-quote="madman" data-source="post: 153727" data-attributes="member: 13851"><p>Using the newer <a href="https://tru-t.org/" target="_blank"><span style="font-size: 18px"><strong>TruT Free Testosterone Calculator by FPT</strong><span style="color: rgb(0, 0, 0)">.....</span></span></a>which has been show to be on par with results obtained by the <strong><span style="color: rgb(251, 160, 38)">gold standard Equilibrium Dialysis</span></strong> than your FT (trough) is <span style="color: rgb(184, 49, 47)"><strong>26.23 ng/dL</strong> </span>(over the mean of the reference range).</p><p></p><p></p><p></p><p></p><p><span style="color: rgb(0, 0, 0)"><strong>TT 705 ng/dL,</strong> </span><span style="color: rgb(184, 49, 47)"><strong>SHBG 15.9 nmol/L</strong></span><span style="color: rgb(0, 0, 0)"> and </span><span style="color: rgb(44, 130, 201)"><strong>Albumin 4.3 g/dL (mean)</strong> </span><span style="color: rgb(0, 0, 0)">than </span><span style="color: rgb(184, 49, 47)"><strong>FT is 26.23 ng/dL</strong></span><span style="color: rgb(0, 0, 0)"><strong> (just over the mean 23.5 ng/dL of the reference range </strong></span><span style="color: rgb(184, 49, 47)"><strong>16-31 ng/dL</strong></span><span style="color: rgb(0, 0, 0)"><strong>)</strong></span></p><p>[ATTACH=full]7869[/ATTACH]</p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p><strong><span style="color: rgb(184, 49, 47)">1. What value should I shoot for</span></strong></p><p></p><p>- most would aim for a moderate----->high/normal FT level at trough</p><p></p><p>- many men will do well having FT levels in the 25-30 ng/dL range and others may need/feel better running higher levels 30-50 ng/dL range.....as we know every individual is different.....mind you it is highly doubtful one would need to run FT levels well over the reference range.....let alone 50+ ng/dL to benefit from testosterone replacement therapy!</p><p></p><p>-many can easily do well having FT trough levels at the top of the reference range (high/normal).....especially if thyroid/adrenals are healthy</p><p></p><p>- keep in mind it is also critical that we are looking at trough FT levels so one needs to understand that protocol (dose/injection frequency) will have a big impact on what FT level to aim for.....if one is injecting larger doses of T less frequently (once weekly) than one would want to make sure FT levels at trough are not too high as peak levels early in the week would be much higher as oppose to one injecting lower doses more frequently as in daily or EOD than one could get away with running a higher FT at trough as peak levels would not be too extreme</p><p></p><p>- you need to find what FT level you feel best at overall (relief/improvement of low-t symptoms) while keeping blood markers healthy.....let alone preventing/minimizing any potential side-effects</p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p><strong>2. <span style="color: rgb(184, 49, 47)">What method of calculation is correct?</span></strong></p><p></p><p></p><p>no-brainer here!</p><p></p><p></p><p></p><p></p><p></p><p></p><p>From a previous thread:<a href="https://www.excelmale.com/forum/threads/gmans-test-prop-labs.18708/page-2" target="_blank">Gman's Test Prop Labs</a></p><p></p><p></p><p></p><p></p><p>Straight to the point:</p><p></p><p></p><p><strong>*</strong> <span style="color: rgb(26, 188, 156)">highlighted in green- <strong>refer to</strong> <strong>the linear law-of-mass-action model/equation Vermueulen</strong> </span><strong><span style="color: rgb(26, 188, 156)">(cFTV)</span></strong></p><p></p><p><strong>*</strong><span style="color: rgb(44, 130, 201)">highlighted in blue- <strong>refer to the new Multi-step Dynamic Binding Model with Complex Allostery (TruT calculated)</strong> </span></p><p></p><p></p><p></p><p></p><p></p><p><strong>[0387]</strong> <strong><span style="color: rgb(184, 49, 47)">Relation between Percent FT with Total Testosterone and SHBG. </span><span style="color: rgb(251, 160, 38)">Intra-dimer complex allostery suggests that SHBG can regulate FT fraction over a wide range of total testosterone concentrations without getting saturated.</span></strong> <strong><span style="color: rgb(44, 130, 201)">Indeed, it was found that percent FT calculated using the new model changed very modestly over a wide range of total testosterone concentrations.</span></strong> <strong><span style="color: rgb(26, 188, 156)">In contrast, the Vermeulen's equation suggests a negative relation between percent FT and total testosterone.</span> <span style="color: rgb(44, 130, 201)">Furthermore, as SHBG concentrations increase, percent FT calculated using our new model shows only a modest decline</span></strong> <strong><span style="color: rgb(26, 188, 156)">in contrast to the marked decline in percent FT calculated using Vermeulen's equation.</span></strong></p></blockquote><p></p>
[QUOTE="madman, post: 153727, member: 13851"] Using the newer [URL='https://tru-t.org/'][SIZE=18px][B]TruT Free Testosterone Calculator by FPT[/B][COLOR=rgb(0, 0, 0)].....[/COLOR][/SIZE][/URL]which has been show to be on par with results obtained by the [B][COLOR=rgb(251, 160, 38)]gold standard Equilibrium Dialysis[/COLOR][/B] than your FT (trough) is [COLOR=rgb(184, 49, 47)][B]26.23 ng/dL[/B] [/COLOR](over the mean of the reference range). [COLOR=rgb(0, 0, 0)][B]TT 705 ng/dL,[/B] [/COLOR][COLOR=rgb(184, 49, 47)][B]SHBG 15.9 nmol/L[/B][/COLOR][COLOR=rgb(0, 0, 0)] and [/COLOR][COLOR=rgb(44, 130, 201)][B]Albumin 4.3 g/dL (mean)[/B] [/COLOR][COLOR=rgb(0, 0, 0)]than [/COLOR][COLOR=rgb(184, 49, 47)][B]FT is 26.23 ng/dL[/B][/COLOR][COLOR=rgb(0, 0, 0)][B] (just over the mean 23.5 ng/dL of the reference range [/B][/COLOR][COLOR=rgb(184, 49, 47)][B]16-31 ng/dL[/B][/COLOR][COLOR=rgb(0, 0, 0)][B])[/B][/COLOR] [ATTACH=full]7869[/ATTACH] [B][COLOR=rgb(184, 49, 47)]1. What value should I shoot for[/COLOR][/B] - most would aim for a moderate----->high/normal FT level at trough - many men will do well having FT levels in the 25-30 ng/dL range and others may need/feel better running higher levels 30-50 ng/dL range.....as we know every individual is different.....mind you it is highly doubtful one would need to run FT levels well over the reference range.....let alone 50+ ng/dL to benefit from testosterone replacement therapy! -many can easily do well having FT trough levels at the top of the reference range (high/normal).....especially if thyroid/adrenals are healthy - keep in mind it is also critical that we are looking at trough FT levels so one needs to understand that protocol (dose/injection frequency) will have a big impact on what FT level to aim for.....if one is injecting larger doses of T less frequently (once weekly) than one would want to make sure FT levels at trough are not too high as peak levels early in the week would be much higher as oppose to one injecting lower doses more frequently as in daily or EOD than one could get away with running a higher FT at trough as peak levels would not be too extreme - you need to find what FT level you feel best at overall (relief/improvement of low-t symptoms) while keeping blood markers healthy.....let alone preventing/minimizing any potential side-effects [B]2. [COLOR=rgb(184, 49, 47)]What method of calculation is correct?[/COLOR][/B] no-brainer here! From a previous thread:[URL='https://www.excelmale.com/forum/threads/gmans-test-prop-labs.18708/page-2']Gman's Test Prop Labs[/URL] Straight to the point: [B]*[/B] [COLOR=rgb(26, 188, 156)]highlighted in green- [B]refer to[/B] [B]the linear law-of-mass-action model/equation Vermueulen[/B] [/COLOR][B][COLOR=rgb(26, 188, 156)](cFTV)[/COLOR][/B] [B]*[/B][COLOR=rgb(44, 130, 201)]highlighted in blue- [B]refer to the new Multi-step Dynamic Binding Model with Complex Allostery (TruT calculated)[/B] [/COLOR] [B][0387][/B] [B][COLOR=rgb(184, 49, 47)]Relation between Percent FT with Total Testosterone and SHBG. [/COLOR][COLOR=rgb(251, 160, 38)]Intra-dimer complex allostery suggests that SHBG can regulate FT fraction over a wide range of total testosterone concentrations without getting saturated.[/COLOR][/B] [B][COLOR=rgb(44, 130, 201)]Indeed, it was found that percent FT calculated using the new model changed very modestly over a wide range of total testosterone concentrations.[/COLOR][/B] [B][COLOR=rgb(26, 188, 156)]In contrast, the Vermeulen's equation suggests a negative relation between percent FT and total testosterone.[/COLOR] [COLOR=rgb(44, 130, 201)]Furthermore, as SHBG concentrations increase, percent FT calculated using our new model shows only a modest decline[/COLOR][/B] [B][COLOR=rgb(26, 188, 156)]in contrast to the marked decline in percent FT calculated using Vermeulen's equation.[/COLOR][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Determining optimal Free T value
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