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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Detailed Labs of 42yr old healthy with some recent sexual symptoms
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<blockquote data-quote="Cataceous" data-source="post: 214423" data-attributes="member: 38109"><p>A counterpoint is that androgens have the opposite effect of estrogens on SHBG, tending to drive it down. Additionally, in another thread we've been discussing the effects of reducing SHBG. I'm starting to believe that this in isolation has minimal influence on the free hormone levels. However, if you were inclined to experiment then it's possible that micro-dosing an AI would push you in the desired direction, with higher free testosterone and at least relatively lower free estradiol. In absolute terms your free and total estradiol levels aren't actually very high, so you'd have to be very cautious with AI dosing. In the case of anastrozole I would start with only 15-20 mcg per day or so.</p><p></p><p>Our bodies regulate testosterone production via the levels of free androgens and, more importantly, free estrogens. As an aromatase inhibitor starts to reduce production of estradiol the body compensates with increased testosterone production, raising free testosterone. Via aromatization the higher testosterone prevents estradiol from dropping so much, but you've still accomplished the goal of raising testosterone relative to estradiol. This may also reduce SHBG to an extent. It may seem paradoxical, but lower SHBG reduces the total hormone levels. So you shouldn't be disappointed if total testosterone doesn't move or even goes down. You have to instead look at what the free hormones are doing.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 214423, member: 38109"] A counterpoint is that androgens have the opposite effect of estrogens on SHBG, tending to drive it down. Additionally, in another thread we've been discussing the effects of reducing SHBG. I'm starting to believe that this in isolation has minimal influence on the free hormone levels. However, if you were inclined to experiment then it's possible that micro-dosing an AI would push you in the desired direction, with higher free testosterone and at least relatively lower free estradiol. In absolute terms your free and total estradiol levels aren't actually very high, so you'd have to be very cautious with AI dosing. In the case of anastrozole I would start with only 15-20 mcg per day or so. Our bodies regulate testosterone production via the levels of free androgens and, more importantly, free estrogens. As an aromatase inhibitor starts to reduce production of estradiol the body compensates with increased testosterone production, raising free testosterone. Via aromatization the higher testosterone prevents estradiol from dropping so much, but you've still accomplished the goal of raising testosterone relative to estradiol. This may also reduce SHBG to an extent. It may seem paradoxical, but lower SHBG reduces the total hormone levels. So you shouldn't be disappointed if total testosterone doesn't move or even goes down. You have to instead look at what the free hormones are doing. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Detailed Labs of 42yr old healthy with some recent sexual symptoms
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