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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Desperate advice needed quickly..too late?
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<blockquote data-quote="madman" data-source="post: 223489" data-attributes="member: 13851"><p>Stick to your current protocol for now especially if you feel good overall and your blood markers are healthy.</p><p></p><p>If you are struggling with sides/keeping blood markers healthy then you would easily have room to lower your dose and bring down your trough FT which is going to be very high seeing as you are hitting a very high TT 1350 ng/dL 6 days post-injection.</p><p></p><p>Even if you have high/highish SHBG your trough FT would still be high running a very high trough TT 1350 ng/dL.</p><p></p><p>Again your peak TT, FT, and estradiol level will be much higher.</p><p></p><p>You would need to have your FT retested using the most accurate assays (ED or UF) to know where it truly sits.</p><p></p><p>I would also test your SHBG to see where it currently sits mind you it will most likely be lower than your pre-trt level as high doses of T can drive down SHBG.</p><p></p><p>SHBG is important to know as it can dictate what injection frequency may suit you best.</p><p></p><p>Most men on trt will see a reduction in SHBG but it depends on the protocol/individual.</p><p></p><p>Some men may notice a bigger drop whereas many others not so much.</p><p></p><p>My SHBG pre-trt was 34 nmol/L and on trt 150 mg T/week split into twice-weekly injections (75 mg every 3.5 days) my SHBG hovers around 30-32 nmol/L and this is 6 years in on trt.</p><p></p><p>Your true trough would be 7 days post-injection just before your next shot and I would not be too concerned that you tested 1 day early as there will not be a big difference in blood levels if you had tested at the true trough.</p><p></p><p>The downfall of injecting a high dose of T once weekly is that there will be a big difference in the peak--->trough let alone blood levels will not be as stable throughout the week which can lead to the rollercoaster effect (ups/downs) which can have a negative impact on mood/energy/libido/erectile function for some.</p><p></p><p>Although some men prefer injecting once weekly I would say it is more common to split up the weekly dose and inject twice-weekly (every 3.5 days) let alone many are following an EOD or daily injection protocol using lower doses of T.</p><p></p><p>Injecting more frequently will clip the peak--->trough let alone result in more stable blood levels throughout the week.</p><p></p><p>If anything the main differences between pre-trt/post-trt results aside from an increase in TT, FT, estradiol, and DHT would be LH/FSH (trt results in shutdown of the HPGA), SHBG (may be driven down), HDL (may be driven down), and it is a given that your RBCs, hemoglobin and hematocrit will increase.</p><p></p><p>Make sure to get a full thyroid panel and salivary cortisol (four-point) as dysfunctional thyroid/adrenals can have a negative impact on the effectiveness of your TRT protocol.</p><p></p><p>Many struggling with sides let alone feeling shitty overall are running too high a trough FT level.</p><p></p><p>The more T is better mentality has taken over let alone many are clueless as to where their FT level truly sits due to relying on inaccurate testing methods.</p><p></p><p>You can put the blame on all of the misinformed brozzz on those dime-a-dozen forums/gootube spewing that mumbo jumbo!</p><p></p><p>To make matters even worse unfortunately many doctors (GPs/endos/uros/TRT clinics) are also clueless when it comes to testing Free Testosterone!</p><p></p><p>Moving forward make sure to test using the most accurate assays TT/estradiol/DHT (LC/MS-MS) and FT (Equilibrium Dialysis or Ultrafiltration).</p><p></p><p>Always test at the true trough (lowest point) just before your next injection.</p><p></p><p>I prefer Labcorps FT (EU) which has a reference range of<strong><em> 5.00-21.00 ng/dL.</em></strong></p><p></p><p><a href="https://www.labcorp.com/tests/070038/testosterone-free-equilibrium-ultrafiltration-with-total-testosterone-lc-ms-ms" target="_blank">070038: Testosterone, Free, Equilibrium Ultrafiltration With Total Testosterone, LC/MS-MS | Labcorp</a></p><p></p><p><strong><u>Free</u>:</strong><em> equilibrium ultrafiltration; </em><strong><u>tota</u>l:</strong><em> liquid chromatography/tandem mass spectrometry (LC/MS-MS)</em></p></blockquote><p></p>
[QUOTE="madman, post: 223489, member: 13851"] Stick to your current protocol for now especially if you feel good overall and your blood markers are healthy. If you are struggling with sides/keeping blood markers healthy then you would easily have room to lower your dose and bring down your trough FT which is going to be very high seeing as you are hitting a very high TT 1350 ng/dL 6 days post-injection. Even if you have high/highish SHBG your trough FT would still be high running a very high trough TT 1350 ng/dL. Again your peak TT, FT, and estradiol level will be much higher. You would need to have your FT retested using the most accurate assays (ED or UF) to know where it truly sits. I would also test your SHBG to see where it currently sits mind you it will most likely be lower than your pre-trt level as high doses of T can drive down SHBG. SHBG is important to know as it can dictate what injection frequency may suit you best. Most men on trt will see a reduction in SHBG but it depends on the protocol/individual. Some men may notice a bigger drop whereas many others not so much. My SHBG pre-trt was 34 nmol/L and on trt 150 mg T/week split into twice-weekly injections (75 mg every 3.5 days) my SHBG hovers around 30-32 nmol/L and this is 6 years in on trt. Your true trough would be 7 days post-injection just before your next shot and I would not be too concerned that you tested 1 day early as there will not be a big difference in blood levels if you had tested at the true trough. The downfall of injecting a high dose of T once weekly is that there will be a big difference in the peak--->trough let alone blood levels will not be as stable throughout the week which can lead to the rollercoaster effect (ups/downs) which can have a negative impact on mood/energy/libido/erectile function for some. Although some men prefer injecting once weekly I would say it is more common to split up the weekly dose and inject twice-weekly (every 3.5 days) let alone many are following an EOD or daily injection protocol using lower doses of T. Injecting more frequently will clip the peak--->trough let alone result in more stable blood levels throughout the week. If anything the main differences between pre-trt/post-trt results aside from an increase in TT, FT, estradiol, and DHT would be LH/FSH (trt results in shutdown of the HPGA), SHBG (may be driven down), HDL (may be driven down), and it is a given that your RBCs, hemoglobin and hematocrit will increase. Make sure to get a full thyroid panel and salivary cortisol (four-point) as dysfunctional thyroid/adrenals can have a negative impact on the effectiveness of your TRT protocol. Many struggling with sides let alone feeling shitty overall are running too high a trough FT level. The more T is better mentality has taken over let alone many are clueless as to where their FT level truly sits due to relying on inaccurate testing methods. You can put the blame on all of the misinformed brozzz on those dime-a-dozen forums/gootube spewing that mumbo jumbo! To make matters even worse unfortunately many doctors (GPs/endos/uros/TRT clinics) are also clueless when it comes to testing Free Testosterone! Moving forward make sure to test using the most accurate assays TT/estradiol/DHT (LC/MS-MS) and FT (Equilibrium Dialysis or Ultrafiltration). Always test at the true trough (lowest point) just before your next injection. I prefer Labcorps FT (EU) which has a reference range of[B][I] 5.00-21.00 ng/dL.[/I][/B] [URL='https://www.labcorp.com/tests/070038/testosterone-free-equilibrium-ultrafiltration-with-total-testosterone-lc-ms-ms']070038: Testosterone, Free, Equilibrium Ultrafiltration With Total Testosterone, LC/MS-MS | Labcorp[/URL] [B][U]Free[/U]:[/B][I] equilibrium ultrafiltration; [/I][B][U]tota[/U]l:[/B][I] liquid chromatography/tandem mass spectrometry (LC/MS-MS)[/I] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Desperate advice needed quickly..too late?
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