ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
General Health & Fitness
Health & Wellness
Decline in Testosterone is Associated with Cognitive Decline in Older Men
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Nelson Vergel" data-source="post: 17215" data-attributes="member: 3"><p><strong>Longitudinal Relationships between Reproductive Hormones and Cognitive Decline in Older Men: The Concord Health and Ageing in Men Project.</strong></p><p></p><p>Hsu B, et al. J Clin Endocrinol Metab. 2015.</p><p></p><p></p><p></p><p><strong>Abstract</strong></p><p></p><p>CONTEXT: The longitudinal relationship between declining levels of reproductive hormones and cognitive function remains unclear in older men. </p><p></p><p>OBJECTIVES: The objective of this study was to examine the temporal relationship between changes in major reproductive hormone levels and cognitive decline over time.</p><p></p><p>DESIGN, SETTING AND PARTICIPANTS: Men aged 70 years and older from the Concord Health and Ageing in Men Project (CHAMP) were assessed at baseline (2005-2007, n=1705), 2-years follow-up (2007-2009, n=1367) and 5-years follow-up (2010-2013, n=958). Main Outcomes and Measures: At all assessments, testosterone (T), dihydrotestosterone (DHT), estradiol (E2), and estrone (E1) were measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS), and SHBG, LH, and FSH by immunoassay. Dementia was diagnosed at baseline by clinical assessment and review by a specialist panel. Cognitive function was measured at all three assessments by the Mini Mental State Examination (MMSE).</p><p></p><p>RESULTS: None of the baseline reproductive hormones predicted cognitive decline in men without dementia over 5-years. However, the change in serum hormones over time was associated with cognitive decline. In univariate analysis, change in all the studied hormones, except for E2, was significantly associated with cognitive decline. However, in multivariate-adjusted models accounting for potential confounders, only change in serum T (&#946;=0.067), DHT (&#946;=0.394), cFT (&#946;=0.005) and E1 (&#946;=0.009) remained significantly (p<0.05) associated with cognitive decline. Men who had dementia at baseline had significantly greater decline in serum T levels, but not in other studied hormones, over the 5-years.</p><p></p><p>CONCLUSIONS: Our findings show that decline in androgen status is associated with cognitive decline in older men, but the causality of this association requires further elucidation.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 17215, member: 3"] [B]Longitudinal Relationships between Reproductive Hormones and Cognitive Decline in Older Men: The Concord Health and Ageing in Men Project.[/B] Hsu B, et al. J Clin Endocrinol Metab. 2015. [B]Abstract[/B] CONTEXT: The longitudinal relationship between declining levels of reproductive hormones and cognitive function remains unclear in older men. OBJECTIVES: The objective of this study was to examine the temporal relationship between changes in major reproductive hormone levels and cognitive decline over time. DESIGN, SETTING AND PARTICIPANTS: Men aged 70 years and older from the Concord Health and Ageing in Men Project (CHAMP) were assessed at baseline (2005-2007, n=1705), 2-years follow-up (2007-2009, n=1367) and 5-years follow-up (2010-2013, n=958). Main Outcomes and Measures: At all assessments, testosterone (T), dihydrotestosterone (DHT), estradiol (E2), and estrone (E1) were measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS), and SHBG, LH, and FSH by immunoassay. Dementia was diagnosed at baseline by clinical assessment and review by a specialist panel. Cognitive function was measured at all three assessments by the Mini Mental State Examination (MMSE). RESULTS: None of the baseline reproductive hormones predicted cognitive decline in men without dementia over 5-years. However, the change in serum hormones over time was associated with cognitive decline. In univariate analysis, change in all the studied hormones, except for E2, was significantly associated with cognitive decline. However, in multivariate-adjusted models accounting for potential confounders, only change in serum T (β=0.067), DHT (β=0.394), cFT (β=0.005) and E1 (β=0.009) remained significantly (p<0.05) associated with cognitive decline. Men who had dementia at baseline had significantly greater decline in serum T levels, but not in other studied hormones, over the 5-years. CONCLUSIONS: Our findings show that decline in androgen status is associated with cognitive decline in older men, but the causality of this association requires further elucidation. [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
General Health & Fitness
Health & Wellness
Decline in Testosterone is Associated with Cognitive Decline in Older Men
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top