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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Deca (nandrolone) added to trt and wow!!
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<blockquote data-quote="madman" data-source="post: 164516" data-attributes="member: 13851"><p><span style="color: rgb(184, 49, 47)">How do you explain the fact that I had the exact same total T as another guy, same exact SHBG as him, he actually had a higher albumin level, we both used quest diagnostics to get our blood drawn, and yet his free T was about double mine?</span></p><p></p><p><span style="color: rgb(0, 0, 0)">- are you slow or just plain stupid?..... inaccurate testing methods whether using the direct immunoassay or the linear law-of-mass action calculated Vermeulen.</span></p><p></p><p>Again if you doubt the TruT calculated method than get back to me when you finally have your FT tested using an accurate testing method..... Equilibrium Dialysis or Ultrafiiltration.</p><p></p><p>How many times does this need to be repeated.</p><p></p><p></p><p><span style="color: rgb(184, 49, 47)">What about Dr. Lichten who says that nandrolone doesn’t lower SHBG, but binds to SHBG, and consequently free’s up more free T.</span></p><p></p><p>- proviron, danazol, stanozolol, oxandrolone all have an effect on SHBG.....what is your point</p><p></p><p><span style="color: rgb(184, 49, 47)">You’re saying that you know more than a well known doctor in the field of hormone therapy? </span></p><p></p><p>- never stated such</p><p></p><p><span style="color: rgb(184, 49, 47)">You and you’re ridiculous Tru-T calculator that pumps out results based off of 2 labs. It will never work and/or apply to HRT because SHBG isn’t just a number. Two men with total testosterone levels of 1000, and identical SHBG levels can have two completely different levels of free T.</span></p><p></p><p>A simpleton you are!</p><p></p><p>You clearly have no clue on the newer research regarding SHBG:T binding.</p><p></p><p><span style="color: rgb(0, 0, 0)">You are an idiot to state such as </span>three heavy weights in the field are behind the invention of <strong><span style="color: rgb(184, 49, 47)">TruT.</span></strong></p><p></p><p><strong>Ravi Jasuja, Shalender Bhasin and Mikhail N Zakharov.</strong></p><p></p><p></p><p></p><p></p><p><strong>ABSTRACT</strong></p><p></p><p>- the measurement of testosterone(T) levels is central to the diagnosis of androgen disorders, such as hypogonadism in men and polycystic ovary syndrome (PCOS) in women</p><p></p><p>- circulating t is bound with high affinity to sex hormone binding globulin (SHBG) and with substantially lower affinity to albumin; only the free fraction is biologically active</p><p></p><p>- conditions that affect SHBG concentrations, such as aging and obesity, alter total T but not free T concentrations; in these conditions, the determination of free t is necessary to obtain an accurate assessment of androgen status</p><p></p><p>- <span style="color: rgb(26, 188, 156)"><strong>tracer analog method, the most widely used method for free T, has been shown to be inaccurate</strong></span></p><p></p><p>- equilibrium dialysis method is, technically difficult to implement and standardize, and is not available in most hospital laboratories, leading the Endocrine Society's Expert Panel to conclude that?? the calculation of free testosterone is the most useful estimate of free testosterone in plasma??</p><p></p><p>- <strong><span style="color: rgb(184, 49, 47)">therefore, there is an unmet need for algorithms that provide accurate estimates of free T that match those derived from equilibrium dialysis</span></strong></p><p></p><p>-<span style="color: rgb(184, 49, 47)"> <strong>we have designed a novel and accurate TruTTM algorithm for the determination of free T, based on the characterization of testosterones binding to SHBG using modern biophysical techniques</strong></span></p><p></p><p><span style="color: rgb(0, 0, 0)">-</span><span style="color: rgb(184, 49, 47)"><strong> we have discovered that testosterone's binding to SHBG is a dynamic multistep process that includes allosteric interaction between the two binding sites on an SHBG dimer</strong></span></p><p></p><p>- <strong><span style="color: rgb(184, 49, 47)">our computational frame-work incorporates the correct binding parameters derived experimentally in these studies, the non-linear dynamics in T:SHBG association, and allsotery</span></strong></p><p></p><p><strong>- <span style="color: rgb(184, 49, 47)">in phase I studies , we demonstrated that TruTTM algorithm provides accurate free T values that match those obtained using the equilibrium dialysis in healthy and hypogonadal men</span></strong></p><p></p><p><strong>- <span style="color: rgb(26, 188, 156)">we have also shown that the </span></strong><span style="color: rgb(26, 188, 156)"><strong>binding parameters that have formed the basis of previous equations (e.g., Vermeulen) are incorrect, and that free T values derived using these equations deviate substantially from </strong></span><strong><span style="color: rgb(26, 188, 156)">free T measured by equilibrium dialysis</span></strong></p><p></p><p><span style="color: rgb(0, 0, 0)">-</span><strong><span style="color: rgb(184, 49, 47)"> the </span></strong><span style="color: rgb(184, 49, 47)"><strong>phase I studies have led to adoption of the TruTTM algorithm at </strong></span><strong><span style="color: rgb(184, 49, 47)">several institutions</span></strong></p><p></p><p><strong>- <span style="color: rgb(44, 130, 201)">the phase II program will continue the development of the TruTTM algorithm </span><span style="color: rgb(184, 49, 47)">by validating it in common conditions characterized by altered SHBG concentration, </span><span style="color: rgb(44, 130, 201)">such as obesity and aging (AIM 1), in healthy women across the menstrual cycle, and in women with PCOS (AIM 2)</span></strong></p><p></p><p><strong>- <span style="color: rgb(44, 130, 201)">we will generate population-based reference ranges for free T (AIM 3)</span></strong></p><p></p><p><strong>- <span style="color: rgb(44, 130, 201)">phase II also includes plans for commercialization of the TruTTM algorithm using a HIPAA compliant infrastructure for its clinical adoption</span></strong></p><p></p><p><strong>-<span style="color: rgb(44, 130, 201)">the phase II program will provide validation of TruTTM algorithm in the two most common clinical indications for free T measurement? men suspected of hypogonadism and altered SHBG levels, and women with hyperandrogenic disorders</span></strong></p><p></p><p><strong>- <span style="color: rgb(44, 130, 201)">it will also enable the development of a HIPAA compliant platform that can be embedded into electronic medical record for wider clinical adoption and for improving clinical care</span></strong> </p><p></p><p></p><p>Key points:</p><p></p><p><strong>*</strong> <strong>- <span style="color: rgb(184, 49, 47)">in phase I studies , we demonstrated that TruTTM algorithm provides accurate free T values that match those obtained using the equilibrium dialysis in healthy and hypogonadal men</span></strong></p><p></p><p><strong>- <span style="color: rgb(44, 130, 201)">the phase II program will continue the development of the TruTTM algorithm </span><span style="color: rgb(184, 49, 47)">by validating it in common conditions characterized by altered SHBG concentration, </span><span style="color: rgb(44, 130, 201)">such as obesity and aging (AIM 1), in healthy women across the menstrual cycle, and in women with PCOS (AIM 2)</span></strong></p><p></p><p><strong>- <span style="color: rgb(44, 130, 201)">we will generate population-based reference ranges for free T (AIM 3)</span></strong></p><p></p><p><strong>- <span style="color: rgb(44, 130, 201)">phase II also includes plans for commercialization of the TruTTM algorithm using a HIPAA compliant infrastructure for its clinical adoption</span></strong></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p>From what I understand Phase II is almost done and it is just a matter of time before.....<span style="color: rgb(184, 49, 47)"><strong>"commercialization of the TruTTM algorithm using a HIPAA compliant infrastructure for its clinical adoption"</strong></span></p><p><span style="color: rgb(184, 49, 47)"></span></p><p><span style="color: rgb(0, 0, 0)">I have already given everyone a heads up on what is coming and again if anyone is doubting the validity of the TruT algorithm than at least have the sense to use an accurate testing method such as the gold standard ED or Ultrafiltration before ranting and raving about where your FT level sits.</span></p><p></p><p>As they say stupid is as stupid does!</p><p></p><p></p><p><span style="color: rgb(184, 49, 47)">Prior to TRT, I had my labs tested twice, and both times my free T was bottom of the barrel, and I had all the symptoms to match. Yet the tru T calculator had me at 22.44. Which one do you think was accurate, the tests that match the symptoms, or the calculator results that is supposedly “the best”? Nobody’s gonna use ur stupid calculator because it doesn’t match up with symptoms. So who’s spreading poor information now? All your advice is theoretical. In the real world, theory only goes so far.</span></p><p></p><p>This was all explained to you numerous times yet you are still in denial.....you sound like a scorn child to say the least!</p></blockquote><p></p>
[QUOTE="madman, post: 164516, member: 13851"] [COLOR=rgb(184, 49, 47)]How do you explain the fact that I had the exact same total T as another guy, same exact SHBG as him, he actually had a higher albumin level, we both used quest diagnostics to get our blood drawn, and yet his free T was about double mine?[/COLOR] [COLOR=rgb(0, 0, 0)]- are you slow or just plain stupid?..... inaccurate testing methods whether using the direct immunoassay or the linear law-of-mass action calculated Vermeulen.[/COLOR] Again if you doubt the TruT calculated method than get back to me when you finally have your FT tested using an accurate testing method..... Equilibrium Dialysis or Ultrafiiltration. How many times does this need to be repeated. [COLOR=rgb(184, 49, 47)]What about Dr. Lichten who says that nandrolone doesn’t lower SHBG, but binds to SHBG, and consequently free’s up more free T.[/COLOR] - proviron, danazol, stanozolol, oxandrolone all have an effect on SHBG.....what is your point [COLOR=rgb(184, 49, 47)]You’re saying that you know more than a well known doctor in the field of hormone therapy? [/COLOR] - never stated such [COLOR=rgb(184, 49, 47)]You and you’re ridiculous Tru-T calculator that pumps out results based off of 2 labs. It will never work and/or apply to HRT because SHBG isn’t just a number. Two men with total testosterone levels of 1000, and identical SHBG levels can have two completely different levels of free T.[/COLOR] A simpleton you are! You clearly have no clue on the newer research regarding SHBG:T binding. [COLOR=rgb(0, 0, 0)]You are an idiot to state such as [/COLOR]three heavy weights in the field are behind the invention of [B][COLOR=rgb(184, 49, 47)]TruT.[/COLOR][/B] [B]Ravi Jasuja, Shalender Bhasin and Mikhail N Zakharov.[/B] [B]ABSTRACT[/B] - the measurement of testosterone(T) levels is central to the diagnosis of androgen disorders, such as hypogonadism in men and polycystic ovary syndrome (PCOS) in women - circulating t is bound with high affinity to sex hormone binding globulin (SHBG) and with substantially lower affinity to albumin; only the free fraction is biologically active - conditions that affect SHBG concentrations, such as aging and obesity, alter total T but not free T concentrations; in these conditions, the determination of free t is necessary to obtain an accurate assessment of androgen status - [COLOR=rgb(26, 188, 156)][B]tracer analog method, the most widely used method for free T, has been shown to be inaccurate[/B][/COLOR] - equilibrium dialysis method is, technically difficult to implement and standardize, and is not available in most hospital laboratories, leading the Endocrine Society's Expert Panel to conclude that?? the calculation of free testosterone is the most useful estimate of free testosterone in plasma?? - [B][COLOR=rgb(184, 49, 47)]therefore, there is an unmet need for algorithms that provide accurate estimates of free T that match those derived from equilibrium dialysis[/COLOR][/B] -[COLOR=rgb(184, 49, 47)] [B]we have designed a novel and accurate TruTTM algorithm for the determination of free T, based on the characterization of testosterones binding to SHBG using modern biophysical techniques[/B][/COLOR] [B][COLOR=rgb(184, 49, 47)][/COLOR][/B] [COLOR=rgb(0, 0, 0)]-[/COLOR][COLOR=rgb(184, 49, 47)][B] we have discovered that testosterone's binding to SHBG is a dynamic multistep process that includes allosteric interaction between the two binding sites on an SHBG dimer[/B][/COLOR] - [B][COLOR=rgb(184, 49, 47)]our computational frame-work incorporates the correct binding parameters derived experimentally in these studies, the non-linear dynamics in T:SHBG association, and allsotery[/COLOR][/B] [B]- [COLOR=rgb(184, 49, 47)]in phase I studies , we demonstrated that TruTTM algorithm provides accurate free T values that match those obtained using the equilibrium dialysis in healthy and hypogonadal men[/COLOR][/B] [B]- [COLOR=rgb(26, 188, 156)]we have also shown that the [/COLOR][/B][COLOR=rgb(26, 188, 156)][B]binding parameters that have formed the basis of previous equations (e.g., Vermeulen) are incorrect, and that free T values derived using these equations deviate substantially from [/B][/COLOR][B][COLOR=rgb(26, 188, 156)]free T measured by equilibrium dialysis[/COLOR][/B] [COLOR=rgb(0, 0, 0)]-[/COLOR][B][COLOR=rgb(184, 49, 47)] the [/COLOR][/B][COLOR=rgb(184, 49, 47)][B]phase I studies have led to adoption of the TruTTM algorithm at [/B][/COLOR][B][COLOR=rgb(184, 49, 47)]several institutions[/COLOR][/B] [B]- [COLOR=rgb(44, 130, 201)]the phase II program will continue the development of the TruTTM algorithm [/COLOR][COLOR=rgb(184, 49, 47)]by validating it in common conditions characterized by altered SHBG concentration, [/COLOR][COLOR=rgb(44, 130, 201)]such as obesity and aging (AIM 1), in healthy women across the menstrual cycle, and in women with PCOS (AIM 2)[/COLOR][/B] [B]- [COLOR=rgb(44, 130, 201)]we will generate population-based reference ranges for free T (AIM 3)[/COLOR][/B] [B]- [COLOR=rgb(44, 130, 201)]phase II also includes plans for commercialization of the TruTTM algorithm using a HIPAA compliant infrastructure for its clinical adoption[/COLOR][/B] [B]-[COLOR=rgb(44, 130, 201)]the phase II program will provide validation of TruTTM algorithm in the two most common clinical indications for free T measurement? men suspected of hypogonadism and altered SHBG levels, and women with hyperandrogenic disorders[/COLOR][/B] [B]- [COLOR=rgb(44, 130, 201)]it will also enable the development of a HIPAA compliant platform that can be embedded into electronic medical record for wider clinical adoption and for improving clinical care[/COLOR][/B][COLOR=rgb(44, 130, 201)] [/COLOR] Key points: [B]*[/B] [B]- [COLOR=rgb(184, 49, 47)]in phase I studies , we demonstrated that TruTTM algorithm provides accurate free T values that match those obtained using the equilibrium dialysis in healthy and hypogonadal men[/COLOR][/B] [B]- [COLOR=rgb(44, 130, 201)]the phase II program will continue the development of the TruTTM algorithm [/COLOR][COLOR=rgb(184, 49, 47)]by validating it in common conditions characterized by altered SHBG concentration, [/COLOR][COLOR=rgb(44, 130, 201)]such as obesity and aging (AIM 1), in healthy women across the menstrual cycle, and in women with PCOS (AIM 2)[/COLOR][/B] [B]- [COLOR=rgb(44, 130, 201)]we will generate population-based reference ranges for free T (AIM 3)[/COLOR][/B] [B]- [COLOR=rgb(44, 130, 201)]phase II also includes plans for commercialization of the TruTTM algorithm using a HIPAA compliant infrastructure for its clinical adoption[/COLOR][/B] From what I understand Phase II is almost done and it is just a matter of time before.....[COLOR=rgb(184, 49, 47)][B]"commercialization of the TruTTM algorithm using a HIPAA compliant infrastructure for its clinical adoption"[/B] [/COLOR] [COLOR=rgb(0, 0, 0)]I have already given everyone a heads up on what is coming and again if anyone is doubting the validity of the TruT algorithm than at least have the sense to use an accurate testing method such as the gold standard ED or Ultrafiltration before ranting and raving about where your FT level sits.[/COLOR] As they say stupid is as stupid does! [COLOR=rgb(184, 49, 47)]Prior to TRT, I had my labs tested twice, and both times my free T was bottom of the barrel, and I had all the symptoms to match. Yet the tru T calculator had me at 22.44. Which one do you think was accurate, the tests that match the symptoms, or the calculator results that is supposedly “the best”? Nobody’s gonna use ur stupid calculator because it doesn’t match up with symptoms. So who’s spreading poor information now? All your advice is theoretical. In the real world, theory only goes so far.[/COLOR] This was all explained to you numerous times yet you are still in denial.....you sound like a scorn child to say the least! [/QUOTE]
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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Deca (nandrolone) added to trt and wow!!
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