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<blockquote data-quote="Tommy Wall" data-source="post: 125356" data-attributes="member: 2384"><p><a href="http://www.ergo-log.com/alpha-gpc-gave-man-79-uncontrollable-libido.html" target="_blank">Alpha-GPC gave man (79) uncontrollable libido</a></p><p></p><p>From the report:</p><p>"<span style="font-size: 22px"><strong>Case Report</strong></span></p><p>An otherwise healthy 79-year-old man came to our clinic for memory loss. Neurological examination, hematochemical tests, including blood cell count, coagulation, autoimmunity markers, thyroid hormones, homocysteine, vitamins and folate and brain CT were within the normal range. Neuropsychological evaluation showed an isolated deficit in short term memory with no functional impact on daily activity: the Mini-mental State Examination (MMSE) showed a 28/30 score. Thus, MCI diagnosis was supposed and oral choline supplementation (i.e., choline alphoscerate, a precursor of the phosphatidylcholine) was prescribed at a <strong>dosage of 1200 mg/day.</strong></p><p></p><p><strong>After 6 weeks of regular choline ingestion</strong>, the patient showed a significant increase in libido with sexual urges, even in inappropriate places. His wife, a healthy 70-year-old woman, said that her husband had unexpectedly changed his sexual behavior: they usually had regular sexual intercourse no more than once a month, but, in the last weeks, he wanted to engage her in sexual activity at least three times a day and often asked her for oral sex.</p><p></p><p>Moreover, the patient was very annoyed and nervous when his wife refused sexual contacts; thus, he started masturbating “to alleviate his psychological discomfort.”</p><p>Interestingly, while on choline, the patient and his wife reported a significant improvement in erectile function. Because of this abnormal sexual behavior, choline was withdrawn and hypersexuality receded after about 5 days.</p><p></p><p>Before choline discontinuation, the patient’s sex hormone levels, including total (7 ng/ml) and free testosterone (0.14 ng/ml), were within the normal range. Intriguingly, since the patient was “proud” of his sexual potency while on choline, he spontaneously and secretively ingested oral choline for about another month with a consequent hypersexuality.</p><p></p><p>The patient resumed his “normal” sexual behavior after complete withdrawal of choline intake.</p><p></p><p></p><p><strong>Choline is the precursor of acetylcholine, a parasympathetic neurotransmitter that facilitates genital blood flow engorgement: this peripheral mechanism of action may partially explain the patient’s improvement in erectile function.</strong> <strong>Nevertheless, it is also known that citicholine, a choline-derivate, helps the release of the neurotransmitter dopamine, which is directly involved in increasing libido</strong> (Agut, Ortiz, & Wurtman, <a href="https://link.springer.com/article/10.1007%2Fs10508-013-0137-6#CR1" target="_blank">2000</a>).</p><p></p><p><strong>Interestingly, choline may be converted in trimethylglicyne (TMG) and dimethylglycine (DMG), which may be considered as “libido boosters” since they are involved, as methyl donors, in the metabolism of various hormones and neurotransmitters implicated in mood and sexual pleasure. </strong>Thus, this complex centrally-acting mechanism might play a key role in inducing hypersexuality in predisposed individuals. Indeed, as it becomes evident that single nucleotide polymorphisms (SNPs) in humans can create metabolic inefficiencies (Zeisel, <a href="https://link.springer.com/article/10.1007%2Fs10508-013-0137-6#CR14" target="_blank">2011</a>), it is possible that SNPs genes involved in acetylcholine (and/or other neurotransmitters) metabolism may have altered our patient’s choline response. Moreover, since testosterone levels were normal while the patient was on choline, a possible role of this sexual hormone in inducing the hypersexual behavior may be ruled out.</p><p></p><p>In conclusion, as hypersexuality may be an underreported and overlooked adverse effect of drugs and dietary supplements acting on the cholinergic and aminergic pathways in predisposed individuals, this should be considered when treating and counseling older patients with inappropriate sexual behaviors."</p></blockquote><p></p>
[QUOTE="Tommy Wall, post: 125356, member: 2384"] [URL='http://www.ergo-log.com/alpha-gpc-gave-man-79-uncontrollable-libido.html']Alpha-GPC gave man (79) uncontrollable libido[/URL] From the report: "[SIZE=22px][B]Case Report[/B][/SIZE] An otherwise healthy 79-year-old man came to our clinic for memory loss. Neurological examination, hematochemical tests, including blood cell count, coagulation, autoimmunity markers, thyroid hormones, homocysteine, vitamins and folate and brain CT were within the normal range. Neuropsychological evaluation showed an isolated deficit in short term memory with no functional impact on daily activity: the Mini-mental State Examination (MMSE) showed a 28/30 score. Thus, MCI diagnosis was supposed and oral choline supplementation (i.e., choline alphoscerate, a precursor of the phosphatidylcholine) was prescribed at a [B]dosage of 1200 mg/day.[/B] [B]After 6 weeks of regular choline ingestion[/B], the patient showed a significant increase in libido with sexual urges, even in inappropriate places. His wife, a healthy 70-year-old woman, said that her husband had unexpectedly changed his sexual behavior: they usually had regular sexual intercourse no more than once a month, but, in the last weeks, he wanted to engage her in sexual activity at least three times a day and often asked her for oral sex. Moreover, the patient was very annoyed and nervous when his wife refused sexual contacts; thus, he started masturbating “to alleviate his psychological discomfort.” Interestingly, while on choline, the patient and his wife reported a significant improvement in erectile function. Because of this abnormal sexual behavior, choline was withdrawn and hypersexuality receded after about 5 days. Before choline discontinuation, the patient’s sex hormone levels, including total (7 ng/ml) and free testosterone (0.14 ng/ml), were within the normal range. Intriguingly, since the patient was “proud” of his sexual potency while on choline, he spontaneously and secretively ingested oral choline for about another month with a consequent hypersexuality. The patient resumed his “normal” sexual behavior after complete withdrawal of choline intake. [B]Choline is the precursor of acetylcholine, a parasympathetic neurotransmitter that facilitates genital blood flow engorgement: this peripheral mechanism of action may partially explain the patient’s improvement in erectile function.[/B] [B]Nevertheless, it is also known that citicholine, a choline-derivate, helps the release of the neurotransmitter dopamine, which is directly involved in increasing libido[/B] (Agut, Ortiz, & Wurtman, [URL='https://link.springer.com/article/10.1007%2Fs10508-013-0137-6#CR1']2000[/URL]). [B]Interestingly, choline may be converted in trimethylglicyne (TMG) and dimethylglycine (DMG), which may be considered as “libido boosters” since they are involved, as methyl donors, in the metabolism of various hormones and neurotransmitters implicated in mood and sexual pleasure. [/B]Thus, this complex centrally-acting mechanism might play a key role in inducing hypersexuality in predisposed individuals. Indeed, as it becomes evident that single nucleotide polymorphisms (SNPs) in humans can create metabolic inefficiencies (Zeisel, [URL='https://link.springer.com/article/10.1007%2Fs10508-013-0137-6#CR14']2011[/URL]), it is possible that SNPs genes involved in acetylcholine (and/or other neurotransmitters) metabolism may have altered our patient’s choline response. Moreover, since testosterone levels were normal while the patient was on choline, a possible role of this sexual hormone in inducing the hypersexual behavior may be ruled out. In conclusion, as hypersexuality may be an underreported and overlooked adverse effect of drugs and dietary supplements acting on the cholinergic and aminergic pathways in predisposed individuals, this should be considered when treating and counseling older patients with inappropriate sexual behaviors." [/QUOTE]
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