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Thanks for replying! I was put on an ai from the beginning of trt with defy. Before trt I had a urologist put me on 50mg Clomid daily. I made it a month, e2 was 60 10 days after my last dose  of the Clomid and I was a basket case. Highest I’ve had my estrogen on trt was around 38 e2 sensitive but my total Test was around 800 and free test was about 35 at the time. That was on 180 test cyp weekly with HCG at the time. I felt fine with that e2 but I also had high free t as well so I guess the ratio of the two were ok. I am a pretty big dude (6’8, 260 pounds) but I’m not sure if that has anything to do with normal doses not getting me up to good levels . I’d like to use the least amount possible but it seems the amount is more than most.