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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Daily Intramuscular injections.
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<blockquote data-quote="Cataceous" data-source="post: 207348" data-attributes="member: 38109"><p>This is a poor analogy because the pharmacodynamics of oral and transdermal administration of pregnenolone can be quite different. In contrast, the pharmacodynamics of IM and SC injections of testosterone esters are the same. Testosterone esters are relatively inert until the esters are cleaved. Regardless of injection method, this cleaving doesn't occur until the esters reach the bloodstream. This leaves the modest variability in the pharmacokinetics as the only plausible explanation for differences, assuming no loss of dose.</p><p></p><p></p><p>That's a straw man argument. If someone thinks he does better with IM injections then nobody's telling him to stop. We're pushing back against the incorrect statement that SC injections are ineffective for "most" and the similarly wrong idea that "most" men need more than 100 mg per week on TRT. There's abundant and solid scientific evidence on these points, so it's not simply a difference of opinions. It's science versus myth.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 207348, member: 38109"] This is a poor analogy because the pharmacodynamics of oral and transdermal administration of pregnenolone can be quite different. In contrast, the pharmacodynamics of IM and SC injections of testosterone esters are the same. Testosterone esters are relatively inert until the esters are cleaved. Regardless of injection method, this cleaving doesn't occur until the esters reach the bloodstream. This leaves the modest variability in the pharmacokinetics as the only plausible explanation for differences, assuming no loss of dose. That's a straw man argument. If someone thinks he does better with IM injections then nobody's telling him to stop. We're pushing back against the incorrect statement that SC injections are ineffective for "most" and the similarly wrong idea that "most" men need more than 100 mg per week on TRT. There's abundant and solid scientific evidence on these points, so it's not simply a difference of opinions. It's science versus myth. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Daily Intramuscular injections.
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