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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Daily Injections- what about HCG?
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<blockquote data-quote="KSPhD" data-source="post: 70211" data-attributes="member: 15297"><p>Vince, </p><p></p><p>My understanding is exogenous T shuts down leydig cells endogenous production of T by negative feedback on the hypothalmic pituitary axis, which reduces LH secretion from the pituitary. </p><p></p><p>The leydig cells and sertoli cells (which produce sperm) are in close proximity to one another. The sertoli cells in part have a blood-testes barrier, thus any T you inject and any test you produce that ends up in the circulation will be unlikely to reach the sertoli cells in sufficient concentration. </p><p></p><p>However, because the Leydig cells are in close proximity to the sertoli cells some of the T that is naturally produced can diffuse easily to the Sertoli cells. In contrast, the T you supplement exogenously goes into the blood stream from the interstitial fluid and thus can't reach the sertoli cells. This is what shuts down spermatogenesis. HCG works by mimicking LH, which maintains the Leydig cells T production, and thus maintains spermatogenesis.</p></blockquote><p></p>
[QUOTE="KSPhD, post: 70211, member: 15297"] Vince, My understanding is exogenous T shuts down leydig cells endogenous production of T by negative feedback on the hypothalmic pituitary axis, which reduces LH secretion from the pituitary. The leydig cells and sertoli cells (which produce sperm) are in close proximity to one another. The sertoli cells in part have a blood-testes barrier, thus any T you inject and any test you produce that ends up in the circulation will be unlikely to reach the sertoli cells in sufficient concentration. However, because the Leydig cells are in close proximity to the sertoli cells some of the T that is naturally produced can diffuse easily to the Sertoli cells. In contrast, the T you supplement exogenously goes into the blood stream from the interstitial fluid and thus can't reach the sertoli cells. This is what shuts down spermatogenesis. HCG works by mimicking LH, which maintains the Leydig cells T production, and thus maintains spermatogenesis. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Daily Injections- what about HCG?
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