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Like many guys, my concerns are the long term potential of scar tissue and the daily commitment of injections. Like most everything, it comes down to the individual's perception of cost-benefit. If someone, such as me, feels pretty good and the various lab numbers are in line with a twice-a-week protocol, there's no need to change. However if you're experiencing some of the challenges that guys have that make the decision to go daily, it's certainly worth giving it a go. I imagine the daily routine would settled in after a while and would eventually get to be a non-issue. Mixing injection spots obviously would help and I know some diabetes guys inject multiple times daily, but a lot of those guys also have tremendous issues with scar tissue. Many of those forums have several theads on scar tissue.