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Fig. 4 Effect of D-chiro-inositol (DCI) treatment on estrone (E1) levels. E1 levels from 10 male volunteers at baseline (t0) and after 30 days of treatment (t1) with 1 g DCI per day are presented as a median value of E1 (box plots) (p = 0.0020; Wilcoxon signed rank-sum test). Symbol explanation: see caption of Fig. 1a; b individual E1 levels (before-after treatment). The graph reports the values for each volunteer participating in the study

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