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Ugh, I wish there were places that cared about carrying out studies in regards to HRT like this. Sucks in a way that there’s no money for big pharma to make off of HRT. If there was, I’m sure we’d have much more studies like the one ur asking for

But there’s definitely a lot more in play than we think, when it comes to esters. I personally can’t explain all the reasons that they have differing effects, but I’ve seen enough examples and anecdotes over the past decade plus of researching and being in the HRT game to know that the ester has more of an effect than we think. I can speculate and theorize why, but would love more scientific and exact answers one day