ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Cypionate: Half-Life and Steady-State
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Gman86" data-source="post: 69523" data-attributes="member: 15043"><p>Very good question seaexplorer. Probably a question many guys have. The answer is pretty simple luckily. Once you reach a steady state, this doesn't really mean you have a constant level. Let's use 100mg/ week as an example. When you reach a steady state, on shot day, the max you will have in your system is 200mg. There is still peaks and troughs of testosterone cyp throughout the week regardless of whether you have reached a steady state or not. For example, if you shoot 100mg/ week, and you shoot say every Monday, by Sunday you will only have about 100mg left in your system. To get to the 200mg in your system each week, you are relying on that 100mg shot each Monday to boost the amount in your system from 100mg to 200mg. The 100mg already in your system is the build up of all the half lives of the previous injections. So if instead of 100mg once a week, you did 50mg every 3.5 days, before every shot day you would have probably around 150mg in your system. Being in a steady state doesn't mean your levels are extremely consistent, it just means you have a build up in your system from all the previous injections that now adds to the 100mg per week shot you are doing. Steady state just means on shot day the max milligrams in your system is no longer still going up. Before steady state, each week your max in your system was constantly going up. For example, week one you had 100mg in your system. Week 2 you now had 150mg in your system on shot day. Week 3 you had 175mg in your system on shot day. At week 5 and onward, 200mg in your system on shot day is what your max is now consistently going to be, it will no longer raise from here. That is what steady state means. Your levels will still fluctuate during the week due to the peak and trough times of testosterone cypionate. Test cyp peaks around 24-36 hours, and then will continuously go down. So you actually reach your max of 200mg in your system on Tuesday if you inject 100mg every Monday. So as you can see there are still going to be fluctuations even while in a steady state. You also have to factor in SHBG. Low SHBG makes it so you clear the testosterone quicker. In layman's terms, the testosterone just peaks much quicker and starts to decline in your system quicker. So just keep it simple and know that if your SHBG is low, you are going to most likely need to inject everyday, or EOD. Possibly twice per week, but you would have to try that frequency and see if it works for you. Most likely though EOD is going to be the minimum frequency for TRT to be ideal for you. With high SHBG, twice weekly will be perfect. I wouldn't recommend once per week even with a high SHBG, but it could theoretically work. Only way to know is to try. Hope this helps. Not sure if I explained it good or not lol. </p><p></p><p>The takeaway from this though is that the phrase "steady state" is kind of confusing. It just means that the max milligrams in your system on shot day is going to now be steady and consistent. But fluctuations of testosterone levels in-between shots is different. That's peaks and troughs of a medications. Steady state and peaks/ troughs are two completely different things. Just know, even when you've reached a steady state of a medication, peaks and troughs are unchanged. You still have to figure out the best protocol for you to minimize big fluctuations throughout the week. When trying to figure out your dosing frequency, totally ignore the whole steady state thing. That's my best advice. They are two completely different things.</p></blockquote><p></p>
[QUOTE="Gman86, post: 69523, member: 15043"] Very good question seaexplorer. Probably a question many guys have. The answer is pretty simple luckily. Once you reach a steady state, this doesn't really mean you have a constant level. Let's use 100mg/ week as an example. When you reach a steady state, on shot day, the max you will have in your system is 200mg. There is still peaks and troughs of testosterone cyp throughout the week regardless of whether you have reached a steady state or not. For example, if you shoot 100mg/ week, and you shoot say every Monday, by Sunday you will only have about 100mg left in your system. To get to the 200mg in your system each week, you are relying on that 100mg shot each Monday to boost the amount in your system from 100mg to 200mg. The 100mg already in your system is the build up of all the half lives of the previous injections. So if instead of 100mg once a week, you did 50mg every 3.5 days, before every shot day you would have probably around 150mg in your system. Being in a steady state doesn't mean your levels are extremely consistent, it just means you have a build up in your system from all the previous injections that now adds to the 100mg per week shot you are doing. Steady state just means on shot day the max milligrams in your system is no longer still going up. Before steady state, each week your max in your system was constantly going up. For example, week one you had 100mg in your system. Week 2 you now had 150mg in your system on shot day. Week 3 you had 175mg in your system on shot day. At week 5 and onward, 200mg in your system on shot day is what your max is now consistently going to be, it will no longer raise from here. That is what steady state means. Your levels will still fluctuate during the week due to the peak and trough times of testosterone cypionate. Test cyp peaks around 24-36 hours, and then will continuously go down. So you actually reach your max of 200mg in your system on Tuesday if you inject 100mg every Monday. So as you can see there are still going to be fluctuations even while in a steady state. You also have to factor in SHBG. Low SHBG makes it so you clear the testosterone quicker. In layman's terms, the testosterone just peaks much quicker and starts to decline in your system quicker. So just keep it simple and know that if your SHBG is low, you are going to most likely need to inject everyday, or EOD. Possibly twice per week, but you would have to try that frequency and see if it works for you. Most likely though EOD is going to be the minimum frequency for TRT to be ideal for you. With high SHBG, twice weekly will be perfect. I wouldn't recommend once per week even with a high SHBG, but it could theoretically work. Only way to know is to try. Hope this helps. Not sure if I explained it good or not lol. The takeaway from this though is that the phrase "steady state" is kind of confusing. It just means that the max milligrams in your system on shot day is going to now be steady and consistent. But fluctuations of testosterone levels in-between shots is different. That's peaks and troughs of a medications. Steady state and peaks/ troughs are two completely different things. Just know, even when you've reached a steady state of a medication, peaks and troughs are unchanged. You still have to figure out the best protocol for you to minimize big fluctuations throughout the week. When trying to figure out your dosing frequency, totally ignore the whole steady state thing. That's my best advice. They are two completely different things. [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Cypionate: Half-Life and Steady-State
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top