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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Cycling TRT
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<blockquote data-quote="madman" data-source="post: 206742" data-attributes="member: 13851"><p>Again when it comes to the half-life of unesterified T (10-100min) and esterified T (enanthate/cypionate) let alone short-acting prop.....a big difference to say the least.</p><p></p><p>Your HPG axis will be shut down on a daily prop protocol even if you take a day or two off each week as the recovery of the HPG axis will not happen!</p><p></p><p>Natesto Tmax (approx.40min) let alone when dosed 2-3X daily will result in minimal suppression of the HPG axis due to Natestos short-lived peaks/long trough time.</p><p></p><p></p><p><em><strong>*The 24-hour pharmacokinetic profile of testosterone for patients on TNG treatment has two or three discrete peaks (“pulses”) of testosterone <u>provoked by LH secretions that occur on average every 2 hours</u>. <u>A maximal peak of testosterone appears at about 1h (Tmax) followed by a return to endogenous, pre-dose levels, 4-6 hours later (t1/2 ~1h)</u>. The nadir (trough) between doses correlates well with pre-treatment endogenous levels at diagnosis.</strong></em></p><p><em><strong></strong></em></p><p><em><strong>*The unique, pulsatile, pharmacokinetic profile is believed to have limited impact on the HPG axis with <u>significant trough time preserving luteinizing hormone (LH), follicle-stimulating hormone (FSH), endogenous testosterone production, and sperm counts, while also limiting excess RBC production, estradiol, DHT and PSA in clinical trials</u>.</strong></em></p><p></p><p></p><p>The key point here....<em>.<strong>SIGNIFICANT TROUGH TIME</strong></em> <strong><em>in 24hr period.</em></strong></p><p></p><p>The daily prop protocol could never achieve let alone mimic such due to its longer half-life!</p><p></p><p></p><p></p><p></p><p><strong>post #68/70</strong></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/tips-on-how-to-blend-propionate-with-enanthate-or-cypionate.23485/page-4#post-205333[/URL]</p></blockquote><p></p>
[QUOTE="madman, post: 206742, member: 13851"] Again when it comes to the half-life of unesterified T (10-100min) and esterified T (enanthate/cypionate) let alone short-acting prop.....a big difference to say the least. Your HPG axis will be shut down on a daily prop protocol even if you take a day or two off each week as the recovery of the HPG axis will not happen! Natesto Tmax (approx.40min) let alone when dosed 2-3X daily will result in minimal suppression of the HPG axis due to Natestos short-lived peaks/long trough time. [I][B]*The 24-hour pharmacokinetic profile of testosterone for patients on TNG treatment has two or three discrete peaks (“pulses”) of testosterone [U]provoked by LH secretions that occur on average every 2 hours[/U]. [U]A maximal peak of testosterone appears at about 1h (Tmax) followed by a return to endogenous, pre-dose levels, 4-6 hours later (t1/2 ~1h)[/U]. The nadir (trough) between doses correlates well with pre-treatment endogenous levels at diagnosis. *The unique, pulsatile, pharmacokinetic profile is believed to have limited impact on the HPG axis with [U]significant trough time preserving luteinizing hormone (LH), follicle-stimulating hormone (FSH), endogenous testosterone production, and sperm counts, while also limiting excess RBC production, estradiol, DHT and PSA in clinical trials[/U].[/B][/I] The key point here....[I].[B]SIGNIFICANT TROUGH TIME[/B][/I] [B][I]in 24hr period.[/I][/B] The daily prop protocol could never achieve let alone mimic such due to its longer half-life! [B]post #68/70[/B] [URL unfurl="true"]https://www.excelmale.com/forum/threads/tips-on-how-to-blend-propionate-with-enanthate-or-cypionate.23485/page-4#post-205333[/URL] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Cycling TRT
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