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General Health & Fitness
Health & Wellness
Current Landscape of Pharmacotherapies for Sarcopenia
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<blockquote data-quote="madman" data-source="post: 275507" data-attributes="member: 13851"><p><strong>Fig. 2 Signaling pathways in sarcopenia and potential therapeutic agents targeting them.</strong> The blue and red arrows indicate promoting and inhibiting effects to the next step, respectively. 4EBP1 eukaryotic translation initiation factor 4E-binding protein 1, ACE angiotensin-converting enzyme, ACVR activin receptor type 2, Akt protein kinase B, ALK activin receptor-like kinase, AMPK AMP-activated protein kinase, ARB angiotensin type 1 receptor blocker, AT1R angiotensin type 1 receptor, BCAA branched-chain amino acids, GβL G proteinβ-subunit-like protein, GHSR growth hormone secretagogue receptor/ghrelin receptor, FOXO forkhead BOX O, FST follistatin (activin binding protein), IGF-1 insulin-like growth factor, IGFR insulin-like growth factor receptor, MASR mas receptor, MSTN myostatin, mTOR mammalian target of rapamycin, mTORC1 mammalian target of rapamycin complex 1, Nox2 NADPH oxidase II, p70S6K1 ribosomal protein S6 kinase 1, PDK phosphoinositide-dependent protein kinase,PI3K phosphoinositide 3-kinase, PIP2 phosphatidylinositol 45-bisphosphate, PIP3 phosphatidylinositol 345-trisphosphate, Raptorregulatory associated protein of mTOR, Rheb Ras homolog enriched in brain, ROS reactive oxygen species, SARMs selective androgen receptor modulators, Src non-receptor tyrosine kinase, TNFR1 tumor necrosis factor receptor 1, TNF-α tumor necrosis factor-α, TSC tuberous sclerosis complex</p><p>[ATTACH=full]41419[/ATTACH]</p></blockquote><p></p>
[QUOTE="madman, post: 275507, member: 13851"] [B]Fig. 2 Signaling pathways in sarcopenia and potential therapeutic agents targeting them.[/B] The blue and red arrows indicate promoting and inhibiting effects to the next step, respectively. 4EBP1 eukaryotic translation initiation factor 4E-binding protein 1, ACE angiotensin-converting enzyme, ACVR activin receptor type 2, Akt protein kinase B, ALK activin receptor-like kinase, AMPK AMP-activated protein kinase, ARB angiotensin type 1 receptor blocker, AT1R angiotensin type 1 receptor, BCAA branched-chain amino acids, GβL G proteinβ-subunit-like protein, GHSR growth hormone secretagogue receptor/ghrelin receptor, FOXO forkhead BOX O, FST follistatin (activin binding protein), IGF-1 insulin-like growth factor, IGFR insulin-like growth factor receptor, MASR mas receptor, MSTN myostatin, mTOR mammalian target of rapamycin, mTORC1 mammalian target of rapamycin complex 1, Nox2 NADPH oxidase II, p70S6K1 ribosomal protein S6 kinase 1, PDK phosphoinositide-dependent protein kinase,PI3K phosphoinositide 3-kinase, PIP2 phosphatidylinositol 45-bisphosphate, PIP3 phosphatidylinositol 345-trisphosphate, Raptorregulatory associated protein of mTOR, Rheb Ras homolog enriched in brain, ROS reactive oxygen species, SARMs selective androgen receptor modulators, Src non-receptor tyrosine kinase, TNFR1 tumor necrosis factor receptor 1, TNF-α tumor necrosis factor-α, TSC tuberous sclerosis complex [ATTACH type="full"]41419[/ATTACH] [/QUOTE]
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Current Landscape of Pharmacotherapies for Sarcopenia
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