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Thanks for posting. You did good with reaching out to Defy. That endo you were working with was no help, and just seeing that he was working with those silly index and uptake labs for testing the thyroid speaks volumes!


On your current labs, you have some problems taking place in thyroidville, and there's actually a few things from the previous labs that this could stem from ...


FT4 is at 50sh% of reference range, but then your FT3 is at 16%. This is putting adequate demand on TSH, which is responding, but what you're seeing is the bulk of T4 converting to Reverse T3. This is evident with your FT3/RT3 ratio, at 12.4 (20 or higher). Something is shifting T4 to convert at higher rates of RT3 (?). RT3 doesn't have to be over reference range to be problematic. Its serum levels can be reflected by the amount of actual thyroid hormone being produced.


If you added some Synthroid T4 and increased your serum to let's say 70% of reference range, you would then see even higher levels Reverse T3. T4 converts to T3 and Reverse T3, and depending on several variables with your health will be the factor with how much T4 converts to T3 or RT3.


The other factor to this could be iodine and selenium, but everything given, I think it's probably a few other things that's causing some problems. Your last iron serum was at 82, you will want to see that above 120 to make a difference with getting T3 into the cells; 135 could be ideal IMO. However, you have this high ferritin thing going, which I once had too. I'm a carrier for hemochromatosis, but was able to get everything sorted and controlled through blood donation. Have you been tested for this, and/or the MTHFR mutation? Something is off, the liver shouldn't be producing that much unless provoked.


The other thing that would be crucial to see IMO is a full adrenal profile. Not that cheesy single serum sample that the endo ran, but an actual 4x saliva kit, with cortisol and DHEA corrleation, plus an ACTH on top of it. I sense your AM cortisol might be below par, and that also is a KEY component with T3 and thyroid productivity. If you can get one done through ZRT or Canary Club, I will gladly (as will others) provide comments on the circadian profile, total burden, and how it compares with DHEA.


I'm sure others will comment on the other results, but your LH/FSH is definitely note worthy in comparison to your total test serum! You're producing some (not optimal) endogenous testosterone, so either there's some form of Primary Hypo in place (maybe 1 under-performing testicle? or something?), and/or something at the anterior pituitary needs reviewed? I'm sure the team at Defy will be all over it, plus you might need to check it out a little further with a Urologist. That Endo you mentioned ... You said he only does Gel and Clomid ... He didn't give you any Clomid by chance?


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