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In isolation the last two sets of test results do point to primary hypogonadism. What bothers me is that testicular function appears to have been fine in February. In the absence of some acute illness or injury that seems like a pretty short time frame in which to lose testicular function. I wouldn't consider the diagnosis definitive, but you do need to do something, as  it's not healthy to remain in such a hypogonadal state. Have you had more comprehensive lab work to rule out health problems that may be connected, e.g. thyroid status, vitamin D level, etc.? If you are otherwise healthy then I suppose the main choice is between another run with Clomid—or preferably enclomiphene—or else resort to TRT.


If you are not predisposed to androgenic alopecia then TRT will not cause hair loss. If you are so predisposed then TRT can potentially accelerate the process, but you would probably lose hair even without TRT.


TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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