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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Crashed E2
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<blockquote data-quote="DS3" data-source="post: 175118" data-attributes="member: 18514"><p>My estrogenic symptoms are all cognitive in nature, and I follow my bloodwork to support the notion that my symptoms are related to increasing levels of estradiol. I keep my E2 in the range of 50-70 pg/dL, hardly a 'crashed number'. And yes, I take 0.125 mg anastrozole 1x per week to keep it in that range, otherwise, the aforementioned brain fog, memory deficit, and loss of cognitive horsepower are presented; a theme that I have followed and tracked within myself for 5 years. </p><p></p><p>For me, it takes microdosing, DIM/calcium d-glucarate, and the small dosage of weekly anastrozole to maintain cognitive horsepower, sharp memory, and keep the head fog away. Dr. Rob Kominiarek, also a big proponent of not taking AIs, has discussed his evidence-based research from his patients showing that while taking 1 mg 3x weekly, his patients showed signs of osteoporosis in the results of their DEXA scans. As he took them off or reduced their AI dosage, the osteoporosis slowly reversed. Dr. Kominiarek noted that small dosages such as 0.125 mg per week did not appear to contribute to osteoporosis in his patients as he continued to track their reversal of osteoporosis. </p><p></p><p>The evidence that high and/or frequent dosing of anastrozole contributes to osteoporosis, decreased endothelial tissue health, and cognitive decline is not in question. The evidence is there. </p><p></p><p>What is in question and continually argued is should TRT patients who experience symptoms such as the ones that I described (head fog, decreased memory, decreased cognitive horsepower) as I let my E2 creep past ~65 pg/dL, is "should we NEVER take anastrozole?" The answer you are going to give is likely a 'no'. And I will still tell you that the only thing combination that works for me to keep in an optimal zone of 'cognitive function' is the combination of DIM/Calcium d-glucarate (1-2 x per week) and 0.125 mg anastrozole 1x per week. So the answer cannot be to never use anastrozole, but to use sparingly if you have to.</p></blockquote><p></p>
[QUOTE="DS3, post: 175118, member: 18514"] My estrogenic symptoms are all cognitive in nature, and I follow my bloodwork to support the notion that my symptoms are related to increasing levels of estradiol. I keep my E2 in the range of 50-70 pg/dL, hardly a 'crashed number'. And yes, I take 0.125 mg anastrozole 1x per week to keep it in that range, otherwise, the aforementioned brain fog, memory deficit, and loss of cognitive horsepower are presented; a theme that I have followed and tracked within myself for 5 years. For me, it takes microdosing, DIM/calcium d-glucarate, and the small dosage of weekly anastrozole to maintain cognitive horsepower, sharp memory, and keep the head fog away. Dr. Rob Kominiarek, also a big proponent of not taking AIs, has discussed his evidence-based research from his patients showing that while taking 1 mg 3x weekly, his patients showed signs of osteoporosis in the results of their DEXA scans. As he took them off or reduced their AI dosage, the osteoporosis slowly reversed. Dr. Kominiarek noted that small dosages such as 0.125 mg per week did not appear to contribute to osteoporosis in his patients as he continued to track their reversal of osteoporosis. The evidence that high and/or frequent dosing of anastrozole contributes to osteoporosis, decreased endothelial tissue health, and cognitive decline is not in question. The evidence is there. What is in question and continually argued is should TRT patients who experience symptoms such as the ones that I described (head fog, decreased memory, decreased cognitive horsepower) as I let my E2 creep past ~65 pg/dL, is "should we NEVER take anastrozole?" The answer you are going to give is likely a 'no'. And I will still tell you that the only thing combination that works for me to keep in an optimal zone of 'cognitive function' is the combination of DIM/Calcium d-glucarate (1-2 x per week) and 0.125 mg anastrozole 1x per week. So the answer cannot be to never use anastrozole, but to use sparingly if you have to. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Crashed E2
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