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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Crashed E2
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<blockquote data-quote="DS3" data-source="post: 175084" data-attributes="member: 18514"><p>[USER=40184]@Misery[/USER]</p><p></p><p>Article on estrogen's effects on the brain (positive, not taking into consideration over-aromatization that can occur during TRT): <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902157/" target="_blank">Brain Aromatization: Classical Roles and New Perspectives</a></p><p></p><p>Estrogen's Effect On PFC (menopausal women): <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104582/" target="_blank">Estrogen and the Prefrontal Cortex: Towards A New Understanding of Estrogen’s Effects on Executive Functions in the Menopause Transition</a></p><p></p><p>Estrogen's Effect On PFC (menopausal women): <a href="https://www.researchgate.net/publication/11935719_Prefrontal_cortex_as_the_site_of_estrogens_effect_on_cognition" target="_blank">Prefrontal cortex as the site of estrogen's effect on cognition | Request PDF</a></p><p></p><p>So as you gaze through these last two studies, you gain an understanding of how important estrogen is in cognitive function...too little and you lose optimal function in the prefrontal cortex and the hippocampus (among other neuroanatomical structures).</p><p></p><p>I do not have studies providing evidence of what the cognitive ramifications are in men on TRT who experience over-aromatization. However, the deleteries effects of supraphysiological levels of testosterone are known.</p><p></p><p>Neurotoxic Impact of Anabolic Steroids on Primary Neuronal Structure <a href="https://www.sciencedirect.com/science/article/pii/S0306452218307772" target="_blank">Toxic Impact of Anabolic Androgenic Steroids in Primary Rat Cortical Cell Cultures</a></p><p></p><p>From the last study, and others that support its results, it's fairly clear to see that supraphysiological dosages of testosterone, nandrolone, stanozolol, and trenbolone are of high concern as mitochondrial activity in primary neuronal structures were negatively impacted at relatively low supraphysiological concentrations (with nandrolone having the most significant impact at the lowest dosage, and stanozolol actually inducing cellular death).</p><p></p><p>The fact that there are no direct studies demonstrating effects on cognition as a result of over-aromatization is concerning. However, with the myriad studies conducted regarding both the importance of estrogen on cognitive function, as well as the neurotoxic impact of supraphysiological concentrations of testosterone and synthetic derivatives, it is fairly easy to extrapolate and say, "if too much testosterone results in reduced cognitive function, it's likely safe to say that too much estrogen can cause the same deleteries effects."</p><p></p><p>As I have been figuring out my 'optimal' levels in TRT over the past decade, I can say that my cognitive performance raises fairly significantly as my estrogen rises. But, after a 'tipping point' the rise in cognitive performance is met with migraine, brain fog, decreased memory and decreased cognitive horsepower. After I ingest my small weekly dosage of anastrozle (and leave all other hormones/medications the same) the brain fog lifts, migraine disappears, memory increases, and cognitive horsepower resumes.</p></blockquote><p></p>
[QUOTE="DS3, post: 175084, member: 18514"] [USER=40184]@Misery[/USER] Article on estrogen's effects on the brain (positive, not taking into consideration over-aromatization that can occur during TRT): [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902157/']Brain Aromatization: Classical Roles and New Perspectives[/URL] Estrogen's Effect On PFC (menopausal women): [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104582/']Estrogen and the Prefrontal Cortex: Towards A New Understanding of Estrogen’s Effects on Executive Functions in the Menopause Transition[/URL] Estrogen's Effect On PFC (menopausal women): [URL='https://www.researchgate.net/publication/11935719_Prefrontal_cortex_as_the_site_of_estrogens_effect_on_cognition']Prefrontal cortex as the site of estrogen's effect on cognition | Request PDF[/URL] So as you gaze through these last two studies, you gain an understanding of how important estrogen is in cognitive function...too little and you lose optimal function in the prefrontal cortex and the hippocampus (among other neuroanatomical structures). I do not have studies providing evidence of what the cognitive ramifications are in men on TRT who experience over-aromatization. However, the deleteries effects of supraphysiological levels of testosterone are known. Neurotoxic Impact of Anabolic Steroids on Primary Neuronal Structure [URL='https://www.sciencedirect.com/science/article/pii/S0306452218307772']Toxic Impact of Anabolic Androgenic Steroids in Primary Rat Cortical Cell Cultures[/URL] From the last study, and others that support its results, it's fairly clear to see that supraphysiological dosages of testosterone, nandrolone, stanozolol, and trenbolone are of high concern as mitochondrial activity in primary neuronal structures were negatively impacted at relatively low supraphysiological concentrations (with nandrolone having the most significant impact at the lowest dosage, and stanozolol actually inducing cellular death). The fact that there are no direct studies demonstrating effects on cognition as a result of over-aromatization is concerning. However, with the myriad studies conducted regarding both the importance of estrogen on cognitive function, as well as the neurotoxic impact of supraphysiological concentrations of testosterone and synthetic derivatives, it is fairly easy to extrapolate and say, "if too much testosterone results in reduced cognitive function, it's likely safe to say that too much estrogen can cause the same deleteries effects." As I have been figuring out my 'optimal' levels in TRT over the past decade, I can say that my cognitive performance raises fairly significantly as my estrogen rises. But, after a 'tipping point' the rise in cognitive performance is met with migraine, brain fog, decreased memory and decreased cognitive horsepower. After I ingest my small weekly dosage of anastrozle (and leave all other hormones/medications the same) the brain fog lifts, migraine disappears, memory increases, and cognitive horsepower resumes. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Crashed E2
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