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General Health & Fitness
Health & Wellness
Cracking the Code of Cartilage Regeneration Failure
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<blockquote data-quote="madman" data-source="post: 261842" data-attributes="member: 13851"><p><strong>Fig. 3 | Inflammatory events involved in cartilage regeneration and associated therapeutic strategies. </strong>Inflammation in the joint is a common outcome of several processes including cellular insufficiency, mechanical imbalance or metabolic imbalance, and ultimately prevents cartilage regeneration. Joint inflammation results from chemotaxis of immune cells to the joint and M1 polarization of the macrophages, leading to the activation of fibroblasts through pro-inflammatory cytokines (such as IL-1, IL-6, IL-17 and TNF). These molecules aggravate cartilage damage, for example, through promoting receptor activator of nuclear factor-κB ligand (RANKL)-mediated activation of osteoclasts and the production of matrix metalloproteinases (MMPs). Anti-inflammatory strategies are aimed at preventing immune activation through anti-inflammatory pharmaceutical compounds, cell-instructed immunomodulation or genetic modification of cells. The original version of this figure was created with BioRender.com.</p><p>[ATTACH=full]35580[/ATTACH]</p></blockquote><p></p>
[QUOTE="madman, post: 261842, member: 13851"] [B]Fig. 3 | Inflammatory events involved in cartilage regeneration and associated therapeutic strategies. [/B]Inflammation in the joint is a common outcome of several processes including cellular insufficiency, mechanical imbalance or metabolic imbalance, and ultimately prevents cartilage regeneration. Joint inflammation results from chemotaxis of immune cells to the joint and M1 polarization of the macrophages, leading to the activation of fibroblasts through pro-inflammatory cytokines (such as IL-1, IL-6, IL-17 and TNF). These molecules aggravate cartilage damage, for example, through promoting receptor activator of nuclear factor-κB ligand (RANKL)-mediated activation of osteoclasts and the production of matrix metalloproteinases (MMPs). Anti-inflammatory strategies are aimed at preventing immune activation through anti-inflammatory pharmaceutical compounds, cell-instructed immunomodulation or genetic modification of cells. The original version of this figure was created with BioRender.com. [ATTACH type="full"]35580[/ATTACH] [/QUOTE]
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General Health & Fitness
Health & Wellness
Cracking the Code of Cartilage Regeneration Failure
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