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General Health & Fitness
Health & Wellness
Cracking the Code of Cartilage Regeneration Failure
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<blockquote data-quote="madman" data-source="post: 261839" data-attributes="member: 13851"><p><strong>Fig. 1 | Postulated mechanisms of cellular-based strategies for cartilage regeneration.</strong> The ultimate goal of cell-based strategies for cartilage regeneration is to enrich the density of cells competent in activating or undergoing regeneration. These strategies involve either the recruitment of progenitor cells or the enrichment of chondrocytes. The recruitment strategy involves techniques such as microfracture (to promote recruitment of progenitor cells from the bone marrow to fill the defect) or exosome delivery (to promote the homing of progenitor cells that reside nearby). The recruited progenitor cells promote cartilage regeneration by modulating the inflammatory milieu, by inducing chondrogenesis through paracrine signalling, or by directly differentiating into chondrocytes. The chondrocyte enrichment strategy involves cell-delivery techniques such as autologous chondrocyte implantation (ACI) or matrix-assisted autologous chondrocyte implantation (MACI) and the use of agents that target senescence (such as senomorphic and senolytic drugs) to increase the longevity of the chondrocytes. The original version of this figure was created with BioRender.com.</p><p>[ATTACH=full]35575[/ATTACH]</p></blockquote><p></p>
[QUOTE="madman, post: 261839, member: 13851"] [B]Fig. 1 | Postulated mechanisms of cellular-based strategies for cartilage regeneration.[/B] The ultimate goal of cell-based strategies for cartilage regeneration is to enrich the density of cells competent in activating or undergoing regeneration. These strategies involve either the recruitment of progenitor cells or the enrichment of chondrocytes. The recruitment strategy involves techniques such as microfracture (to promote recruitment of progenitor cells from the bone marrow to fill the defect) or exosome delivery (to promote the homing of progenitor cells that reside nearby). The recruited progenitor cells promote cartilage regeneration by modulating the inflammatory milieu, by inducing chondrogenesis through paracrine signalling, or by directly differentiating into chondrocytes. The chondrocyte enrichment strategy involves cell-delivery techniques such as autologous chondrocyte implantation (ACI) or matrix-assisted autologous chondrocyte implantation (MACI) and the use of agents that target senescence (such as senomorphic and senolytic drugs) to increase the longevity of the chondrocytes. The original version of this figure was created with BioRender.com. [ATTACH type="full"]35575[/ATTACH] [/QUOTE]
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General Health & Fitness
Health & Wellness
Cracking the Code of Cartilage Regeneration Failure
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