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General Health & Fitness
Health & Wellness
COVID-19, Pneumonia & Inflammasomes – The Melatonin Connection
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<blockquote data-quote="Cataceous" data-source="post: 174537" data-attributes="member: 38109"><p>Interesting caution against selenium supplementation further down in the article:</p><p></p><p style="margin-left: 20px"><em>Selenium is a strong scavenger of free radicals. Selenium is believed to be effective against viruses such as Ebola, HIV and influenza A virus [47, 48]. However, selenium may also be an effective inhibitor of angiotensin-converting enzyme (ACE) [49, 102]. Patients suffering from cardiovascular diseases, hypertension and diabetes are often prescribed drugs that either inhibit ACE or block angiotensin II type-I receptor (ARB). Both types of drugs increase the expression of ACE2 [51]. </em></p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"><em>The use of selenium during COVID-19 infections therefore, can be problematic. ACE inhibitors actually INCREASE expression of ACE2, and SARS-CoV-2 infects host cells through binding with ACE2 receptors [50]. ACE2 receptors are found on lung epithelial cells, intestines, kidneys and blood vessels. <strong>Thus using ACE inhibitors either through medication or supplements risk elevating COVID-19 infection and developing severe or even fatal disease complications</strong> [51]. </em></p></blockquote><p></p>
[QUOTE="Cataceous, post: 174537, member: 38109"] Interesting caution against selenium supplementation further down in the article: [INDENT][I]Selenium is a strong scavenger of free radicals. Selenium is believed to be effective against viruses such as Ebola, HIV and influenza A virus [47, 48]. However, selenium may also be an effective inhibitor of angiotensin-converting enzyme (ACE) [49, 102]. Patients suffering from cardiovascular diseases, hypertension and diabetes are often prescribed drugs that either inhibit ACE or block angiotensin II type-I receptor (ARB). Both types of drugs increase the expression of ACE2 [51]. [/I][/INDENT] [INDENT][I][/I][/INDENT] [INDENT][I]The use of selenium during COVID-19 infections therefore, can be problematic. ACE inhibitors actually INCREASE expression of ACE2, and SARS-CoV-2 infects host cells through binding with ACE2 receptors [50]. ACE2 receptors are found on lung epithelial cells, intestines, kidneys and blood vessels. [B]Thus using ACE inhibitors either through medication or supplements risk elevating COVID-19 infection and developing severe or even fatal disease complications[/B] [51]. [/I][/INDENT] [/QUOTE]
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General Health & Fitness
Health & Wellness
COVID-19, Pneumonia & Inflammasomes – The Melatonin Connection
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