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I think genetics/age play a large part and all you need to do is adjust dosage and/or frequency of injections, I agree that AI's should never be used, complete poison IMO. Some might only handle 60-70 mg/wk without problems, while others can push 200 mg/wk without problems, who really knows for certain, but I know I do not want to mess with my cardiovascular system like that with Ai's that is completely unsustainable