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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Could the ratio of progesterone to estradiol affect water retention in men on TRT?
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<blockquote data-quote="JoeMatts" data-source="post: 197707" data-attributes="member: 41444"><p>Some more information I've come across from Dr Raymond Peat on the influence of progesterone and estrogen on water retention - from his book, 'From PMS to Menopause':</p><p></p><p>"In animal experiments, I knew that estrogen causes cells to take up water within a few minutes after it reaches the tissue, and that this is at least partly the result of its interfering with the availability of oxygen. Within 40 minutes of administering a large dose of estrogen, the lungs become extremely inefficient at oxygenating the blood. This involves a sudden thickening of the alveolar membranes and the walls of capillaries, simply by taking up water. So, when I saw bulging veins disappear a few minutes after women took progesterone, along with a sudden lifting of extreme depression, I guessed that their circulation had become more efficient, and that better oxygenation had changed their mood."</p><p></p><p>"Then, I repeatedly saw physical changes in other people that were visible within an hour, and that involved a sudden movement of water out of edematous tissues. In many people with damaged joint cartilage (confirmed by various types of examination, including arthroscopy), the joints became mobile in an hour, and by the next day, the defect no longer existed. A man who was purple from emphysema changed color within a few hours, and within a few days was going to work. The bulging eyes of exophthalmic Graves' disease receded into their sockets noticeably within an hour, and were normal the next day. Simply improving the circulation couldn't have done those things. Opposing estrogen's edema-promoting action was involved, but I couldn't imagine any mechanism that could 103 explain such rapid movement of water from the swollen tissue into the blood stream."</p><p></p><p>"One of estrogen's effects is to lower the amount of albumin in the blood. Estrogen causes the liver to synthesize less albumin, partly by causing the messenger RNA to be destabilized and degraded. (Iron can have some similar effects on liver RNA.) When there isn't enough albumin in the blood, water moves from the blood into the tissues. Albumin binds oily substances, and its conformation seems to be opened when it binds them. Progesterone is known to adsorb strongly to proteins- -it has been called a "cardinal adsorbant," meaning that it can bind in ways that cause the protein's adsorptive capacity to change. I believe that progesterone and pregnenolone oppose estrogen in many ways, but the amazing speed with which they can cause major structural changes in the soft tissues convinces me that one of their first sites of action is the albumin molecule, causing its conformation to open in such a way that it is able to more strongly bind water molecules. This physical change in albumin would change the blood's osmotic/oncotic pressure, causing water to flow into capillaries. As the edema is reduced, oxygenation is more efficient, because the pathway for oxygen diffusion becomes shorter."</p><p></p><p>"Albumin has been described as a first line of defense against toxins, since it binds them until the liver is able to degrade them chemically. Progesterone, pregnenolone, and cholesterol are known to increase the organism's resistance to a great variety of toxins. (Selye coined the name "catatoxic steroids" to describe steroids of this type.) If these steroids bind to albumin in a way that opens the protein to increase its binding capacity, that single process could explain the "catatoxic" effect, as well as the anti-edema effect."</p><p></p><p>"When the blood is unable to retain its normal amount of water because of insufficient albumin/sodium, the blood volume is reduced as the tissues become water-logged. This causes the hematocrit (the proportion of cells in a volume of blood) to rise, and this increased packing of red blood cells causes the blood to become more viscous. (Knisely studied this phenomenon in a great variety of sickness.) Increased viscosity and slower flow decreases the bloods ability to deliver oxygen and nutrients to the tissues, including the blood vessel walls, modifying their tone. Slower flow, even without any changes in the fibrin-fibrinogen system itself, increases the formation of clots. This description of progesterone's immediate action is intended to take some of the mystery out of its dramatic effects, but it isn't intended 104 to argue against any of its actions within cells. It serves to give a general picture of how progesterone can systematically reduce stress and its harmful consequences, just by making blood circulation more efficient"</p></blockquote><p></p>
[QUOTE="JoeMatts, post: 197707, member: 41444"] Some more information I've come across from Dr Raymond Peat on the influence of progesterone and estrogen on water retention - from his book, 'From PMS to Menopause': "In animal experiments, I knew that estrogen causes cells to take up water within a few minutes after it reaches the tissue, and that this is at least partly the result of its interfering with the availability of oxygen. Within 40 minutes of administering a large dose of estrogen, the lungs become extremely inefficient at oxygenating the blood. This involves a sudden thickening of the alveolar membranes and the walls of capillaries, simply by taking up water. So, when I saw bulging veins disappear a few minutes after women took progesterone, along with a sudden lifting of extreme depression, I guessed that their circulation had become more efficient, and that better oxygenation had changed their mood." "Then, I repeatedly saw physical changes in other people that were visible within an hour, and that involved a sudden movement of water out of edematous tissues. In many people with damaged joint cartilage (confirmed by various types of examination, including arthroscopy), the joints became mobile in an hour, and by the next day, the defect no longer existed. A man who was purple from emphysema changed color within a few hours, and within a few days was going to work. The bulging eyes of exophthalmic Graves' disease receded into their sockets noticeably within an hour, and were normal the next day. Simply improving the circulation couldn't have done those things. Opposing estrogen's edema-promoting action was involved, but I couldn't imagine any mechanism that could 103 explain such rapid movement of water from the swollen tissue into the blood stream." "One of estrogen's effects is to lower the amount of albumin in the blood. Estrogen causes the liver to synthesize less albumin, partly by causing the messenger RNA to be destabilized and degraded. (Iron can have some similar effects on liver RNA.) When there isn't enough albumin in the blood, water moves from the blood into the tissues. Albumin binds oily substances, and its conformation seems to be opened when it binds them. Progesterone is known to adsorb strongly to proteins- -it has been called a "cardinal adsorbant," meaning that it can bind in ways that cause the protein's adsorptive capacity to change. I believe that progesterone and pregnenolone oppose estrogen in many ways, but the amazing speed with which they can cause major structural changes in the soft tissues convinces me that one of their first sites of action is the albumin molecule, causing its conformation to open in such a way that it is able to more strongly bind water molecules. This physical change in albumin would change the blood's osmotic/oncotic pressure, causing water to flow into capillaries. As the edema is reduced, oxygenation is more efficient, because the pathway for oxygen diffusion becomes shorter." "Albumin has been described as a first line of defense against toxins, since it binds them until the liver is able to degrade them chemically. Progesterone, pregnenolone, and cholesterol are known to increase the organism's resistance to a great variety of toxins. (Selye coined the name "catatoxic steroids" to describe steroids of this type.) If these steroids bind to albumin in a way that opens the protein to increase its binding capacity, that single process could explain the "catatoxic" effect, as well as the anti-edema effect." "When the blood is unable to retain its normal amount of water because of insufficient albumin/sodium, the blood volume is reduced as the tissues become water-logged. This causes the hematocrit (the proportion of cells in a volume of blood) to rise, and this increased packing of red blood cells causes the blood to become more viscous. (Knisely studied this phenomenon in a great variety of sickness.) Increased viscosity and slower flow decreases the bloods ability to deliver oxygen and nutrients to the tissues, including the blood vessel walls, modifying their tone. Slower flow, even without any changes in the fibrin-fibrinogen system itself, increases the formation of clots. This description of progesterone's immediate action is intended to take some of the mystery out of its dramatic effects, but it isn't intended 104 to argue against any of its actions within cells. It serves to give a general picture of how progesterone can systematically reduce stress and its harmful consequences, just by making blood circulation more efficient" [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Could the ratio of progesterone to estradiol affect water retention in men on TRT?
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