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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Could the ratio of progesterone to estradiol affect water retention in men on TRT?
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<blockquote data-quote="xqfq" data-source="post: 155036" data-attributes="member: 38167"><p>I've been experiencing some water retention and I'm trying to see if I can solve it[1]. My E2 LC/MS/MS was 40.4 pg/mL without HCG, and I've since re-added 300IU HCG EOD.</p><p></p><p>I had my progesterone tested yesterday, and it was 0.2 ng/mL, or 200 pg/mL. So my progesterone is at the very low end of the male reference range, but my E2 is at the very top end of the male reference range.</p><p></p><p>So I'm now going to try and raise my progesterone levels. I've read some reports here that guys can raise their progesterone by taking pregnenolone, so I've begun taking 50mg of pregnenolone orally as of today.[2]</p><p></p><p>I'd like to avoid using a progesterone cream if possible, as I believe it may be inconsistent, especially since the "pump" dosage is designed for women.</p><p></p><p>I'll be posting updates as I learn more!</p><p></p><p>---</p><p></p><p><em>1. I can usually control this water retention with diet (eating with a potassium: sodium ratio of 2-3 : 1), but when eating out or socializing, it flares up.</em></p><p><em></em></p><p><em>I'm not on an AI and my current protocol is 44 mg EOD subQ test-e (154mg / week), 300 IU HCG EOD subQ. I was experiencing water retention even without HCG, on 144mg / week test-e, which had my Total T at 664 ng/dL, Free T "direct" 12.6 pg/mL (Range: 8.7-25.1), E2 LC/MS/MS 40.4 pg/mL (Ref: 8 - 35.0), SHBG 45.3 nmol/L. With the 300IU EOD of HCG, my TT is 860 ng/dL and Free T "direct" is 22.8 pg/mL.</em></p><p><em></em></p><p><em>2. I wasn't able to find out any information about the "effective" half life of pregnenolone. From reading around, most guys tend to take a single oral dose each day. Pregnenolone appears to have a "sulfate" form, similar to DHEA / DHEA-S, so I'm hoping the "sulfate" form of pregnenolone allows it to be taken once per day.</em></p><p><em></em></p><p><em>From my reading, progesterone has poor oral bioavailability as well as a very short half life. This Wikipedia article is really good and detailed: Pharmacodynamics of progesterone - Wikipedia. Most guys who supplement with progesterone seem to use a cream, from what I can tell from reading here and elsewhere?</em></p></blockquote><p></p>
[QUOTE="xqfq, post: 155036, member: 38167"] I've been experiencing some water retention and I'm trying to see if I can solve it[1]. My E2 LC/MS/MS was 40.4 pg/mL without HCG, and I've since re-added 300IU HCG EOD. I had my progesterone tested yesterday, and it was 0.2 ng/mL, or 200 pg/mL. So my progesterone is at the very low end of the male reference range, but my E2 is at the very top end of the male reference range. So I'm now going to try and raise my progesterone levels. I've read some reports here that guys can raise their progesterone by taking pregnenolone, so I've begun taking 50mg of pregnenolone orally as of today.[2] I'd like to avoid using a progesterone cream if possible, as I believe it may be inconsistent, especially since the "pump" dosage is designed for women. I'll be posting updates as I learn more! --- [I]1. I can usually control this water retention with diet (eating with a potassium: sodium ratio of 2-3 : 1), but when eating out or socializing, it flares up. I'm not on an AI and my current protocol is 44 mg EOD subQ test-e (154mg / week), 300 IU HCG EOD subQ. I was experiencing water retention even without HCG, on 144mg / week test-e, which had my Total T at 664 ng/dL, Free T "direct" 12.6 pg/mL (Range: 8.7-25.1), E2 LC/MS/MS 40.4 pg/mL (Ref: 8 - 35.0), SHBG 45.3 nmol/L. With the 300IU EOD of HCG, my TT is 860 ng/dL and Free T "direct" is 22.8 pg/mL. 2. I wasn't able to find out any information about the "effective" half life of pregnenolone. From reading around, most guys tend to take a single oral dose each day. Pregnenolone appears to have a "sulfate" form, similar to DHEA / DHEA-S, so I'm hoping the "sulfate" form of pregnenolone allows it to be taken once per day. From my reading, progesterone has poor oral bioavailability as well as a very short half life. This Wikipedia article is really good and detailed: Pharmacodynamics of progesterone - Wikipedia. Most guys who supplement with progesterone seem to use a cream, from what I can tell from reading here and elsewhere?[/I] [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Could the ratio of progesterone to estradiol affect water retention in men on TRT?
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