Could Testosterone Therapy Protect Against Developing Prostate Cancer?

madman

Super Moderator

In this episode, Dr. Brandon and Dr. Morgentaler talk about how emerging research suggests testosterone therapy may not only be safe but could actually help protect against aggressive prostate cancer, while also touching on practical approaches to maintaining sexual connection at midlife.




00:34 Addressing Listener Questions on Sexual Connection
– Dr. Brandon and Dr. Morgentaler discuss practical, therapist-friendly strategies for couples looking to gently reboot intimacy and improve sexual connection at midlife.


04:17 Introduction to Testosterone and Prostate Cancer – The hosts introduce the question of whether testosterone therapy could be protective against prostate cancer, setting the stage for reviewing the latest evidence.


05:06 Historical Perspective on Testosterone Therapy – They review the decades-long belief that testosterone increases prostate cancer risk and explain how this view limited therapy use until more recent decades.


08:15 Recent Research and Findings – They highlight large observational studies and randomized trials showing that testosterone therapy is not linked to higher prostate cancer risk and may even reduce aggressive cancer incidence.


16:26 Concluding Thoughts and Future Directions – The hosts emphasize the need for future randomized trials and discuss how these findings are shifting perspectives on testosterone therapy for men’s health.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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