ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Could my total T drop 795 points in 5 days?
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Cataceous" data-source="post: 206549" data-attributes="member: 38109"><p>I have to admit that because of the short time frame I wasn't thinking of falling SHBG as a significant contributing factor to reduced total testosterone. It's certainly possible if the drop is nontrivial. SHBG is said to have a half-life of seven days. If production totally ceased then nominally you'd lose 40% after five days. Maybe this sets the lower limit. That would seem to be enough to matter. The study you reference shows a more muted response, a 21% drop on average after 10 days for the 25 mg dose of exemestane, and in an environment in which the level of androgens is increasing. I'd like to run some numbers, but I need to think a bit more about the apparent need to base half-lives on free testosterone rather than total.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 206549, member: 38109"] I have to admit that because of the short time frame I wasn't thinking of falling SHBG as a significant contributing factor to reduced total testosterone. It's certainly possible if the drop is nontrivial. SHBG is said to have a half-life of seven days. If production totally ceased then nominally you'd lose 40% after five days. Maybe this sets the lower limit. That would seem to be enough to matter. The study you reference shows a more muted response, a 21% drop on average after 10 days for the 25 mg dose of exemestane, and in an environment in which the level of androgens is increasing. I'd like to run some numbers, but I need to think a bit more about the apparent need to base half-lives on free testosterone rather than total. [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Could my total T drop 795 points in 5 days?
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top