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Could it be? Ageing reversed?
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<blockquote data-quote="BigTex" data-source="post: 243672" data-attributes="member: 43589"><p>In a recent study published in Cell on Jan. 12, Harvard scientists showed that they could manipulate and reverse the aging process in mice by generating DNA repairs.</p><p></p><p>The results of a 13-year, international study show for the first time that breakdown in epigenetic information accelerates aging in mice and that repairing the epigenome can reverse those signs of aging.</p><p></p><p>“For about the past 50 years, popular theory has held that the process of aging is caused in large part by an accumulation of mutation. There’s growing evidence, however, that aging has a significant epigenetic component. That is, the process by which stretches of DNA or the genes are turned on and off,” said the paper’s senior author, David Sinclair, professor of genetics at the Blavatnik Institute at Harvard Medical School and co-director of the Paul F. Glenn Center for Biology of Aging Research.</p><p></p><p>“My colleagues and I believe that not only are epigenetic changes are the primary cause of aging, but that these changes are driven by the ongoing process of DNA breakage and repair,” he continued.</p><p></p><p>“We believe ours is the first study to show epigenetic change as a primary driver of aging in mammals,” Sinclair said.</p><p></p><p>“First, the results need to be replicated in larger mammals and in humans. Studies in nonhuman primates are currently underway,” Harvard said in a statement.</p><p></p><p>“We hope these results are seen as a turning point in our ability to control aging,” said Sinclair. “This is the first study showing that we can have precise control of the biological age of a complex animal; that we can drive it forwards and backwards at will.”</p><p></p><p>[URL unfurl="true"]https://www.cell.com/cell/fulltext/S0092-8674(22)01570-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867422015707%3Fshowall%3Dtrue[/URL]</p><p></p><p>[MEDIA=youtube]PYjPqq8P70s[/MEDIA]</p><p></p><p></p><p>Here is an earlier study: Gene Therapy Mediated Partial Reprogramming Extends Lifespan and Reverses Age-Related Changes in Aged Mice</p><p></p><p>[URL unfurl="true"]https://www.biorxiv.org/content/10.1101/2023.01.04.522507v1.full[/URL]</p></blockquote><p></p>
[QUOTE="BigTex, post: 243672, member: 43589"] In a recent study published in Cell on Jan. 12, Harvard scientists showed that they could manipulate and reverse the aging process in mice by generating DNA repairs. The results of a 13-year, international study show for the first time that breakdown in epigenetic information accelerates aging in mice and that repairing the epigenome can reverse those signs of aging. “For about the past 50 years, popular theory has held that the process of aging is caused in large part by an accumulation of mutation. There’s growing evidence, however, that aging has a significant epigenetic component. That is, the process by which stretches of DNA or the genes are turned on and off,” said the paper’s senior author, David Sinclair, professor of genetics at the Blavatnik Institute at Harvard Medical School and co-director of the Paul F. Glenn Center for Biology of Aging Research. “My colleagues and I believe that not only are epigenetic changes are the primary cause of aging, but that these changes are driven by the ongoing process of DNA breakage and repair,” he continued. “We believe ours is the first study to show epigenetic change as a primary driver of aging in mammals,” Sinclair said. “First, the results need to be replicated in larger mammals and in humans. Studies in nonhuman primates are currently underway,” Harvard said in a statement. “We hope these results are seen as a turning point in our ability to control aging,” said Sinclair. “This is the first study showing that we can have precise control of the biological age of a complex animal; that we can drive it forwards and backwards at will.” [URL unfurl="true"]https://www.cell.com/cell/fulltext/S0092-8674(22)01570-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867422015707%3Fshowall%3Dtrue[/URL] [MEDIA=youtube]PYjPqq8P70s[/MEDIA] Here is an earlier study: Gene Therapy Mediated Partial Reprogramming Extends Lifespan and Reverses Age-Related Changes in Aged Mice [URL unfurl="true"]https://www.biorxiv.org/content/10.1101/2023.01.04.522507v1.full[/URL] [/QUOTE]
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Could it be? Ageing reversed?
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