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General Health & Fitness
Health & Wellness
Coronavirus COVID-19 Update: Hydroxychloroquine and Other Treatments
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<blockquote data-quote="Nelson Vergel" data-source="post: 175482" data-attributes="member: 3"><p><strong>Ophthalmologic safety of long-term hydroxychloroquine sulfate treatment</strong></p><p></p><p>Rynes, Richard I</p><p></p><p>The American Journal of Medicine, 1983, Vol.75(1), pp.35-39</p><p></p><p></p><p>The fear of retinal toxicity has been a major factor limiting the use of chloroquine and hydroxychloroquine. Patients reported to develop retinal toxicity with visual loss usually took daily dosages higher than those currently in use. Toxicity with low dosages (for example, 250 mg per day chloroquine or 400 mg per day hydroxychloroquine) usually reveals pigment abnormalities; associated loss of vision is rare. When 99 patients treated with hydroxychloroquine <strong>for more than one year</strong> were studied prospectively, four patients showed evidence of retinal toxicity; none developed visual loss, and all abnormalities were completely reversible after drug discontinuation. All persons receiving antimalarials should be evaluated by an ophthalmologist at baseline and every six months thereafter. ∗ ∗ The manufacturer's recommendation is that Ophthalmologic examinations be made every three months during long-term therapy.</p><p></p><p>[ATTACH=full]9486[/ATTACH]</p><p></p><p></p><p></p><p><strong>COVID-19 PROTOCOLS BEING STUDIED (all short term treatment):</strong></p><p></p><p>University of Minnesota Post Exposure Study:</p><p></p><p>200mg tablet; 800 mg orally once, followed in 6 to 8 hours by 600 mg, then 600mg once a day for 4 consecutive days</p><p></p><p></p><p>Some Chinese studies:</p><p></p><p>400 mg per day for 5 days</p><p></p><p></p><p>This drug is pretty safe for short term use.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 175482, member: 3"] [B]Ophthalmologic safety of long-term hydroxychloroquine sulfate treatment[/B] Rynes, Richard I The American Journal of Medicine, 1983, Vol.75(1), pp.35-39 The fear of retinal toxicity has been a major factor limiting the use of chloroquine and hydroxychloroquine. Patients reported to develop retinal toxicity with visual loss usually took daily dosages higher than those currently in use. Toxicity with low dosages (for example, 250 mg per day chloroquine or 400 mg per day hydroxychloroquine) usually reveals pigment abnormalities; associated loss of vision is rare. When 99 patients treated with hydroxychloroquine [B]for more than one year[/B] were studied prospectively, four patients showed evidence of retinal toxicity; none developed visual loss, and all abnormalities were completely reversible after drug discontinuation. All persons receiving antimalarials should be evaluated by an ophthalmologist at baseline and every six months thereafter. ∗ ∗ The manufacturer's recommendation is that Ophthalmologic examinations be made every three months during long-term therapy. [ATTACH type="full"]9486[/ATTACH] [B]COVID-19 PROTOCOLS BEING STUDIED (all short term treatment):[/B] University of Minnesota Post Exposure Study: 200mg tablet; 800 mg orally once, followed in 6 to 8 hours by 600 mg, then 600mg once a day for 4 consecutive days Some Chinese studies: 400 mg per day for 5 days This drug is pretty safe for short term use. [/QUOTE]
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General Health & Fitness
Health & Wellness
Coronavirus COVID-19 Update: Hydroxychloroquine and Other Treatments
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