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General Health & Fitness
Health & Wellness
Coronavirus COVID-19 Update: Hydroxychloroquine and Other Treatments
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<blockquote data-quote="Nelson Vergel" data-source="post: 175193" data-attributes="member: 3"><p>This may sound crazy but we have to keep an open mind. A friend from Pakistan sent it to me.</p><p></p><p></p><p>[URL unfurl="true"]https://tansan.com.tr/a-possible-role-for-single-dose-hydroxychloroquine-for-prevention-of-lethal-coronavirus-infection/[/URL]</p><p></p><p></p><p>I checked the package insert</p><p></p><p>Pharmacokinetics: Following a single 200 mg oral dose of PLAQUENIL to healthy males, the mean peak blood concentration of hydroxychloroquine was 129.6 ng/mL, reached in 3.26 hours with a half-life of 537 hours (22.4 days). In the same study, <strong>the plasma peak concentration was 53 ng/mL reached in 3.74 hours with a half-life of 2963 hours (123.5 days)</strong>. Urine hydroxychloroquine levels were still detectable after 3 months with approximately 10% of the dose excreted as the parent drug.</p><p></p><p></p><p>Update on April 20:</p><p></p><p>These two large studies are looking into one per week dosing:</p><p></p><p>[URL unfurl="true"]https://clinicaltrials.gov/ct2/show/NCT04341441[/URL]</p><p></p><p>[URL unfurl="true"]https://clinicaltrials.gov/ct2/show/NCT04333732[/URL]</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 175193, member: 3"] This may sound crazy but we have to keep an open mind. A friend from Pakistan sent it to me. [URL unfurl="true"]https://tansan.com.tr/a-possible-role-for-single-dose-hydroxychloroquine-for-prevention-of-lethal-coronavirus-infection/[/URL] I checked the package insert Pharmacokinetics: Following a single 200 mg oral dose of PLAQUENIL to healthy males, the mean peak blood concentration of hydroxychloroquine was 129.6 ng/mL, reached in 3.26 hours with a half-life of 537 hours (22.4 days). In the same study, [B]the plasma peak concentration was 53 ng/mL reached in 3.74 hours with a half-life of 2963 hours (123.5 days)[/B]. Urine hydroxychloroquine levels were still detectable after 3 months with approximately 10% of the dose excreted as the parent drug. Update on April 20: These two large studies are looking into one per week dosing: [URL unfurl="true"]https://clinicaltrials.gov/ct2/show/NCT04341441[/URL] [URL unfurl="true"]https://clinicaltrials.gov/ct2/show/NCT04333732[/URL] [/QUOTE]
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General Health & Fitness
Health & Wellness
Coronavirus COVID-19 Update: Hydroxychloroquine and Other Treatments
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