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This may sound crazy but we have to keep an open mind.  A friend from Pakistan sent it to me.



[URL unfurl="true"]https://tansan.com.tr/a-possible-role-for-single-dose-hydroxychloroquine-for-prevention-of-lethal-coronavirus-infection/[/URL]



I checked the package insert


Pharmacokinetics: Following a single 200 mg oral dose of PLAQUENIL to healthy males, the mean peak blood concentration of hydroxychloroquine was 129.6 ng/mL, reached in 3.26 hours with a half-life of 537 hours (22.4 days). In the same study, the plasma peak concentration was 53 ng/mL reached in 3.74 hours with a half-life of 2963 hours (123.5 days). Urine hydroxychloroquine levels were still detectable after 3 months with approximately 10% of the dose excreted as the parent drug.



Update on April 20:


These two large studies are looking into one per week dosing:


[URL unfurl="true"]https://clinicaltrials.gov/ct2/show/NCT04341441[/URL]


[URL unfurl="true"]https://clinicaltrials.gov/ct2/show/NCT04333732[/URL]


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