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This may sound crazy but we have to keep an open mind. A friend from Pakistan sent it to me.

[URL unfurl="true"]https://tansan.com.tr/a-possible-role-for-single-dose-hydroxychloroquine-for-prevention-of-lethal-coronavirus-infection/[/URL]

I checked the package insert

Pharmacokinetics: Following a single 200 mg oral dose of PLAQUENIL to healthy males, the mean peak blood concentration of hydroxychloroquine was 129.6 ng/mL, reached in 3.26 hours with a half-life of 537 hours (22.4 days). In the same study, the plasma peak concentration was 53 ng/mL reached in 3.74 hours with a half-life of 2963 hours (123.5 days). Urine hydroxychloroquine levels were still detectable after 3 months with approximately 10% of the dose excreted as the parent drug.

Update on April 20:

These two large studies are looking into one per week dosing:

[URL unfurl="true"]https://clinicaltrials.gov/ct2/show/NCT04341441[/URL]

[URL unfurl="true"]https://clinicaltrials.gov/ct2/show/NCT04333732[/URL]

<blockquote data-quote="Nelson Vergel" data-source="post: 175193" data-attributes="member: 3">This may sound crazy but we have to keep an open mind.&nbsp; A friend from Pakistan sent it to me.[URL unfurl=&quot;true&quot;]https://tansan.com.tr/a-possible-role-for-single-dose-hydroxychloroquine-for-prevention-of-lethal-coronavirus-infection/[/URL]I checked the package insertPharmacokinetics: Following a single 200 mg oral dose of PLAQUENIL to healthy males, the mean peak blood concentration of hydroxychloroquine was 129.6 ng/mL, reached in 3.26 hours with a half-life of 537 hours (22.4 days). In the same study, the plasma peak concentration was 53 ng/mL reached in 3.74 hours with a half-life of 2963 hours (123.5 days). Urine hydroxychloroquine levels were still detectable after 3 months with approximately 10% of the dose excreted as the parent drug.Update on April 20:These two large studies are looking into one per week dosing:[URL unfurl=&quot;true&quot;]https://clinicaltrials.gov/ct2/show/NCT04341441[/URL][URL unfurl=&quot;true&quot;]https://clinicaltrials.gov/ct2/show/NCT04333732[/URL]</blockquote>

[QUOTE="Nelson Vergel, post: 175193, member: 3"] This may sound crazy but we have to keep an open mind. A friend from Pakistan sent it to me. [URL unfurl="true"]https://tansan.com.tr/a-possible-role-for-single-dose-hydroxychloroquine-for-prevention-of-lethal-coronavirus-infection/[/URL] I checked the package insert Pharmacokinetics: Following a single 200 mg oral dose of PLAQUENIL to healthy males, the mean peak blood concentration of hydroxychloroquine was 129.6 ng/mL, reached in 3.26 hours with a half-life of 537 hours (22.4 days). In the same study, [B]the plasma peak concentration was 53 ng/mL reached in 3.74 hours with a half-life of 2963 hours (123.5 days)[/B]. Urine hydroxychloroquine levels were still detectable after 3 months with approximately 10% of the dose excreted as the parent drug. Update on April 20: These two large studies are looking into one per week dosing: [URL unfurl="true"]https://clinicaltrials.gov/ct2/show/NCT04341441[/URL] [URL unfurl="true"]https://clinicaltrials.gov/ct2/show/NCT04333732[/URL] [/QUOTE]

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TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038