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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Contemporary and Emerging Pharmacotherapies for Peyronie’s Disease (Bent Penis)
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<blockquote data-quote="madman" data-source="post: 226609" data-attributes="member: 13851"><p><strong>Highlights box</strong></p><p></p><p><em><strong>● Current clinical guidelines advocate the use of drug therapy as first-line treatment despite the relative sparse scientific evidence and the fact that published studies have significant heterogeneity in methodologies such as a small number of patients, mixed PD features, and limited objective outcome measures </strong></em></p><p><em><strong></strong></em></p><p><em><strong>● Oral drugs may be useful in the early phase of PD and for males who are not interested in surgical intervention, oral drugs can be used as an adjunct with other nonsurgical therapy </strong></em></p><p><em><strong></strong></em></p><p><strong><em>● Intralesional injectable drugs appear more effective than oral drugs but require injection into palpable penile plaque while the optimal intralesional treatment protocol(s) including the amount of drug injection as well as penile remodeling strategy remains unknown</em></strong></p><p></p><p><em><strong>● Combined treatment modality involving various oral and/or intralesional pharmacotherapies together with mechanical devices or clinical psychosexual therapy may provide additional or synergistic benefits for PD patients </strong></em></p><p><em><strong></strong></em></p><p><strong><em>● Future drug therapy will need to incorporate drugs that target matrix metalloproteinases and tissue inhibitors of metalloproteinases as well as various genetic and molecular regulatory pathways involved in the PD</em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 226609, member: 13851"] [B]Highlights box[/B] [I][B]● Current clinical guidelines advocate the use of drug therapy as first-line treatment despite the relative sparse scientific evidence and the fact that published studies have significant heterogeneity in methodologies such as a small number of patients, mixed PD features, and limited objective outcome measures ● Oral drugs may be useful in the early phase of PD and for males who are not interested in surgical intervention, oral drugs can be used as an adjunct with other nonsurgical therapy [/B][/I] [B][I]● Intralesional injectable drugs appear more effective than oral drugs but require injection into palpable penile plaque while the optimal intralesional treatment protocol(s) including the amount of drug injection as well as penile remodeling strategy remains unknown[/I][/B] [I][B]● Combined treatment modality involving various oral and/or intralesional pharmacotherapies together with mechanical devices or clinical psychosexual therapy may provide additional or synergistic benefits for PD patients [/B][/I] [B][I]● Future drug therapy will need to incorporate drugs that target matrix metalloproteinases and tissue inhibitors of metalloproteinases as well as various genetic and molecular regulatory pathways involved in the PD[/I][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Contemporary and Emerging Pharmacotherapies for Peyronie’s Disease (Bent Penis)
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