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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Considering weaning off of TRT
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<blockquote data-quote="MIP1950" data-source="post: 208389" data-attributes="member: 42988"><p>On the practical side, my urologist has patients that only respond when their total is 1500 or higher and it's a given that their free T is also high. The reasons why some men only respond to high doses of testosterone, whether injected, topical or pellets isn't really known and the knowledgeable doctors who prescribe TRT, will treat until there's symptom resolution. I referred to an abstract in Frontiers of Immunology about vitamin D resistance and the two possible causes stated are either VDR polymorphisms or pathogens that block or blunt vitamin D receptors. And the way to treat is to keep titrating until the resistance is overcome. </p><p></p><p>Whether in the case of testosterone or vitamin D or even thyroid resistance, the only practical way is to push the dose but, in the case of testosterone, there could be deleterious effects or problems from prolonged high dosing. It isn't perfect, but until the underlying mechanisms of resistance are discovered and can be corrected, treating until symptom resolution is all we have.</p></blockquote><p></p>
[QUOTE="MIP1950, post: 208389, member: 42988"] On the practical side, my urologist has patients that only respond when their total is 1500 or higher and it's a given that their free T is also high. The reasons why some men only respond to high doses of testosterone, whether injected, topical or pellets isn't really known and the knowledgeable doctors who prescribe TRT, will treat until there's symptom resolution. I referred to an abstract in Frontiers of Immunology about vitamin D resistance and the two possible causes stated are either VDR polymorphisms or pathogens that block or blunt vitamin D receptors. And the way to treat is to keep titrating until the resistance is overcome. Whether in the case of testosterone or vitamin D or even thyroid resistance, the only practical way is to push the dose but, in the case of testosterone, there could be deleterious effects or problems from prolonged high dosing. It isn't perfect, but until the underlying mechanisms of resistance are discovered and can be corrected, treating until symptom resolution is all we have. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Considering weaning off of TRT
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