ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Considering starting TRT although levels are not "clinically low" Feedback would be appreciated
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Cataceous" data-source="post: 200970" data-attributes="member: 38109"><p>As you may have read, what sets Natesto apart is its short half-life. The three daily pulses of testosterone do not cause significant HPTA suppression; there is sufficient time at lower levels to keep the axis functional.</p><p></p><p>Regarding the disruption caused by conventional TRT, it is virtually impossible to "replicate what the body does naturally". At a minimum TRT suppresses upstream hormones, which include LH, FSH, GnRH and kisspeptin. Progesterone, DHEA and pregenolone are sometimes affected. There may also be secondary effects on ACTH and the thyroid hormones. There is a lot of potential for introducing new problems. And that doesn't even get into the dosing issues. We see stories here daily of men taking too much testosterone and having problems with hematocrit, estradiol, etc. All too often, instead of reducing the dose they try to manage the side effects with blood donations and aromatase inhibitors, which makes things even more complicated.</p><p></p><p>It's true that guys with problems are overrepresented in the forums. Nonetheless, I recall seeing some statistics about the overall "churn" rates for various forms of TRT, and it was surprisingly high—suggesting that overall satisfaction is marginal.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 200970, member: 38109"] As you may have read, what sets Natesto apart is its short half-life. The three daily pulses of testosterone do not cause significant HPTA suppression; there is sufficient time at lower levels to keep the axis functional. Regarding the disruption caused by conventional TRT, it is virtually impossible to "replicate what the body does naturally". At a minimum TRT suppresses upstream hormones, which include LH, FSH, GnRH and kisspeptin. Progesterone, DHEA and pregenolone are sometimes affected. There may also be secondary effects on ACTH and the thyroid hormones. There is a lot of potential for introducing new problems. And that doesn't even get into the dosing issues. We see stories here daily of men taking too much testosterone and having problems with hematocrit, estradiol, etc. All too often, instead of reducing the dose they try to manage the side effects with blood donations and aromatase inhibitors, which makes things even more complicated. It's true that guys with problems are overrepresented in the forums. Nonetheless, I recall seeing some statistics about the overall "churn" rates for various forms of TRT, and it was surprisingly high—suggesting that overall satisfaction is marginal. [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Considering starting TRT although levels are not "clinically low" Feedback would be appreciated
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top