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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Consider starting TRT
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<blockquote data-quote="Cataceous" data-source="post: 198911" data-attributes="member: 38109"><p>1. Depending on the study, both Vermeulen and Tru-T free testosterone calculations can correlate pretty well with equilibrium dialysis measurements. Things may get more questionable at the extremes, e.g. high and low SHBG. But also keep in mind that the equilibrium dialysis and ultrafiltration tests are complicated and therefore lack the robustness of the tests for measuring things like total testosterone and SHBG. For this reason I tend to favor the calculated methods.</p><p></p><p>2. Yes, there are options to avoid an undesirable HPTA shutdown. These include Natesto and enclomiphene. Natesto, a testosterone nasal gel, is so short acting that it interferes minimally with HPTA feedback. You get the boost without the suppression of regular TRT. Enclomiphene directly stimulates the HPTA. Results with enclomiphene often look great on paper, but subjectively the reports are mixed. It's still worth a go before TRT, and different protocols should be tried in case one needs to balance the anti-estrogenic effects against the need for some estrogenic activity in areas of the brain.</p><p></p><p>3. Most, but not all guys return to baseline testicular function after stopping TRT. It's possible hCG and/or SERMs speed up the recovery, but they are not essential.</p><p></p><p>4. Enanthate and cypionate are essentially interchangeable. You would not be able to discern a difference unless you had an unusual reaction to a carrier oil or other ingredient.</p><p></p><p>5. In general total absorption is nearly 100% with either IM or SC. SC leads to somewhat slower absorption, which can be a good thing if you're looking for less variation in serum testosterone. SC is good because you're not poking holes in your muscles. Guys may have not-so-nice local reactions to either method and choose the other as a result. SC works better for smaller, more frequent injections; with larger injections it's less practical to have a big bump at the injection site.</p><p></p><p>6. Individual reactions to carrier oils vary. Grapeseed oil has the advantage of lower viscosity, making it faster to load syringes. Higher-viscosity oils such as castor oil can slow absorption of the ester, increasing its apparent half-life.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 198911, member: 38109"] 1. Depending on the study, both Vermeulen and Tru-T free testosterone calculations can correlate pretty well with equilibrium dialysis measurements. Things may get more questionable at the extremes, e.g. high and low SHBG. But also keep in mind that the equilibrium dialysis and ultrafiltration tests are complicated and therefore lack the robustness of the tests for measuring things like total testosterone and SHBG. For this reason I tend to favor the calculated methods. 2. Yes, there are options to avoid an undesirable HPTA shutdown. These include Natesto and enclomiphene. Natesto, a testosterone nasal gel, is so short acting that it interferes minimally with HPTA feedback. You get the boost without the suppression of regular TRT. Enclomiphene directly stimulates the HPTA. Results with enclomiphene often look great on paper, but subjectively the reports are mixed. It's still worth a go before TRT, and different protocols should be tried in case one needs to balance the anti-estrogenic effects against the need for some estrogenic activity in areas of the brain. 3. Most, but not all guys return to baseline testicular function after stopping TRT. It's possible hCG and/or SERMs speed up the recovery, but they are not essential. 4. Enanthate and cypionate are essentially interchangeable. You would not be able to discern a difference unless you had an unusual reaction to a carrier oil or other ingredient. 5. In general total absorption is nearly 100% with either IM or SC. SC leads to somewhat slower absorption, which can be a good thing if you're looking for less variation in serum testosterone. SC is good because you're not poking holes in your muscles. Guys may have not-so-nice local reactions to either method and choose the other as a result. SC works better for smaller, more frequent injections; with larger injections it's less practical to have a big bump at the injection site. 6. Individual reactions to carrier oils vary. Grapeseed oil has the advantage of lower viscosity, making it faster to load syringes. Higher-viscosity oils such as castor oil can slow absorption of the ester, increasing its apparent half-life. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Consider starting TRT
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