Concurrent Use of TRT In Couples Trying to Conceive

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Men's Health

Puneet Masson, M.D., associate professor and director of reproductive urology at the Miller School, and Thomas Masterson, M.D., assistant professor of clinical urology at the Miller School, moderated the Friday men’s health session. Bruce Kava, M.D., professor of clinical urology at the Miller School, and Dr. Wein gave updates on the delivery of men’s health care. They noted that, in contrast to international, multidisciplinary practices, urologists are primarily responsible in the United States.

Several presenters looked at innovative approaches to testosterone replacement therapy (TRT).

“Because TRT is a contraceptive, we typically stop this treatment for couples trying to conceive and give men other medications to make their own testosterone and sperm,” said Dr. Masson


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However, Larry Lipshultz, M.D., professor of urology and chief of male reproductive medicine and surgery at Baylor College of Medicine, presented a novel approach in his talk on “Concurrent Use of TRT In Couples Trying to Conceive.” He demonstrated it can be safe and effective to keep men on TRT while giving them synthetic hormonal therapy to produce sperm.

In a related talk, Joseph Alukal, M.D., M.B.A., director of men’s health at NewYork-Presbyterian/Columbia University Irving Medical Center, said TRT may also be given safely to prostate cancer patients, helping to reduce comorbidities, particularly in older men.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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