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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Comparison of Testosterone Blood Concentrations from Different TRT Products Versus Normal Diurnal Variations
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<blockquote data-quote="madman" data-source="post: 208717" data-attributes="member: 13851"><p><strong>Figure 1. <u>Extrapolated mean steady-state serum total testosterone concentrations</u>. Estimated diurnal T in <u>young men</u> (<u>blue</u>, age range: 23-28 years) and <u>older men</u> (<u>yellow</u>, age range 58- 82 years). <u>Red arrows</u> indicate the time of T administration. <u>Dotted lines</u> indicate Cavg over the dosing interval of 168 hours. <u>Black lines</u> in each panel represent mean steady-state T profiles of <u>A</u>) weekly SC TE administration;<u> B</u>) average mean T profiles for IM TC, TE, and TU over 2 weeks; <u>C</u>) 900 mg subdermal T pellets; D) 4.0 mg daily transdermal patch; E) average mean T profiles of 100 mg TESTIM® /VOGELXO®, 40 mg FORTESTA®, 1.62% AndroGel®, and 2% AXIRON®; F) nasal gel T at day 90 three times daily; G) 30 mg buccal mucoadhesives applied twice daily, and H) twice daily 200 mg oral TU capsules. </strong></p><p><strong></strong></p><p><strong>*For products with ≥1 daily dose, we extrapolated data over 1 week to compare all PK profiles consistently. For products with dosing regimens of longer than a week (eg, IM injections and T pellet implantation), only the PK profile in the first week following dosing is presented; these data do not reflect average concentrations throughout the entire dosing interval. </strong></p><p><strong></strong></p><p><strong>IM, intramuscular; SC, subcutaneous; T, testosterone; TC, testosterone cypionate; TE, testosterone enanthate; TU, testosterone undecanoate.</strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>A. Subcutaneous</strong></p><p><strong>[ATTACH=full]16673[/ATTACH]</strong></p><p><strong></strong></p><p><strong>B. Intramuscular</strong></p><p>[ATTACH=full]16674[/ATTACH]</p><p></p><p><strong>C. Subdermal</strong></p><p>[ATTACH=full]16675[/ATTACH]</p><p></p><p><strong>D. Transdermal</strong></p><p>[ATTACH=full]16676[/ATTACH]</p><p></p><p><strong>E. Topical gels and solutions</strong></p><p>[ATTACH=full]16677[/ATTACH]</p><p></p><p><strong>F. nasal gel</strong></p><p>[ATTACH=full]16678[/ATTACH]</p><p></p><p><strong>G. Buccal mucoadhesives</strong></p><p>[ATTACH=full]16679[/ATTACH]</p><p></p><p><strong>H. Oral capsules</strong></p><p>[ATTACH=full]16680[/ATTACH]</p></blockquote><p></p>
[QUOTE="madman, post: 208717, member: 13851"] [B]Figure 1. [U]Extrapolated mean steady-state serum total testosterone concentrations[/U]. Estimated diurnal T in [U]young men[/U] ([U]blue[/U], age range: 23-28 years) and [U]older men[/U] ([U]yellow[/U], age range 58- 82 years). [U]Red arrows[/U] indicate the time of T administration. [U]Dotted lines[/U] indicate Cavg over the dosing interval of 168 hours. [U]Black lines[/U] in each panel represent mean steady-state T profiles of [U]A[/U]) weekly SC TE administration;[U] B[/U]) average mean T profiles for IM TC, TE, and TU over 2 weeks; [U]C[/U]) 900 mg subdermal T pellets; D) 4.0 mg daily transdermal patch; E) average mean T profiles of 100 mg TESTIM® /VOGELXO®, 40 mg FORTESTA®, 1.62% AndroGel®, and 2% AXIRON®; F) nasal gel T at day 90 three times daily; G) 30 mg buccal mucoadhesives applied twice daily, and H) twice daily 200 mg oral TU capsules. *For products with ≥1 daily dose, we extrapolated data over 1 week to compare all PK profiles consistently. For products with dosing regimens of longer than a week (eg, IM injections and T pellet implantation), only the PK profile in the first week following dosing is presented; these data do not reflect average concentrations throughout the entire dosing interval. IM, intramuscular; SC, subcutaneous; T, testosterone; TC, testosterone cypionate; TE, testosterone enanthate; TU, testosterone undecanoate. A. Subcutaneous [ATTACH type="full" alt="Screenshot (7593).png"]16673[/ATTACH] B. Intramuscular[/B] [ATTACH type="full" alt="Screenshot (7594).png"]16674[/ATTACH] [B]C. Subdermal[/B] [ATTACH type="full" alt="Screenshot (7595).png"]16675[/ATTACH] [B]D. Transdermal[/B] [ATTACH type="full" alt="Screenshot (7596).png"]16676[/ATTACH] [B]E. Topical gels and solutions[/B] [ATTACH type="full" alt="Screenshot (7597).png"]16677[/ATTACH] [B]F. nasal gel[/B] [ATTACH type="full" alt="Screenshot (7598).png"]16678[/ATTACH] [B]G. Buccal mucoadhesives[/B] [ATTACH type="full" alt="Screenshot (7599).png"]16679[/ATTACH] [B]H. Oral capsules[/B] [ATTACH type="full" alt="Screenshot (7600).png"]16680[/ATTACH] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Comparison of Testosterone Blood Concentrations from Different TRT Products Versus Normal Diurnal Variations
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