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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Clomiphene versus Anastrozole for Testosterone Boosting: A study
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<blockquote data-quote="Nelson Vergel" data-source="post: 21427" data-attributes="member: 3"><p>I have not been able to see what doses were used and if they measured sexual function or drive.</p><p><strong></strong></p><p><strong>A Randomized Prospective Double-Blind Comparison Trial of Clomiphene Citrate and Anastrozole in Raising Testosterone in Hypogonadal Infertile Men.</strong></p><p><strong></strong></p><p></p><p>Helo S, et al. J Sex Med. 2015.</p><p></p><p></p><p></p><p>Abstract</p><p></p><p>AIM: <strong>Clomiphene citrate (CC) and anastrozole (AZ)</strong> have been used off label to increase testosterone (T) in hypogonadal infertile men (HIM). Both medications have been shown to increase T with different effects on estradiol (E2) and T-to-E2 ratios. There are no reported randomized trials comparing CC and AZ to improve T levels in HIM. We aimed to establish equivalence of CC vs. AZ with respect to improvement in T levels in HIM.</p><p></p><p>METHODS: We randomized 26 HIM (T less than 350&#8201;ng/dL and normal luteinizing hormone [LH]). Patients were randomized to CC (25&#8201;mg/day) or AZ (1&#8201;mg/day) for 12 weeks. Hormones assayed were total T, free T, E2, LH, follicle stimulating hormone (FSH), and sex hormone binding globulin (SHBG). Patient-reported outcomes were the International Index of Erectile Function, Erection Hardness Scale, and the Androgen Deficiency in the Aging Male questionnaires. Blood tests and questionnaires were recorded at baseline, 6 and 12 weeks. Semen analyses were performed at baseline and 12 weeks.</p><p></p><p>RESULTS: T increased significantly from baseline in both groups at 6 and 12 weeks. There was a significantly larger increase in T and mean increase from baseline in CC vs. AZ (571 vs. 408&#8201;ng/dL, respectively). Whereas E-2 levels increased in the CC group, they decreased in the AZ group. Though both groups demonstrated an increase in T-to-E-2 ratio from baseline, statistic significance at 6 and 12 weeks was only achieved with AZ. Neither group demonstrated significant changes in seminal parameters or patient-reported outcomes.</p><p></p><p>CONCLUSIONS: We failed to demonstrate equivalence of CC vs. AZ. <strong>CC resulted in significantly higher T levels than AZ. AZ resulted in a significantly larger increase in T/E-2 ratio than CC. No significant differences between CC and AZ on seminal parameters.</strong></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 21427, member: 3"] I have not been able to see what doses were used and if they measured sexual function or drive. [B] A Randomized Prospective Double-Blind Comparison Trial of Clomiphene Citrate and Anastrozole in Raising Testosterone in Hypogonadal Infertile Men. [/B] Helo S, et al. J Sex Med. 2015. Abstract AIM: [B]Clomiphene citrate (CC) and anastrozole (AZ)[/B] have been used off label to increase testosterone (T) in hypogonadal infertile men (HIM). Both medications have been shown to increase T with different effects on estradiol (E2) and T-to-E2 ratios. There are no reported randomized trials comparing CC and AZ to improve T levels in HIM. We aimed to establish equivalence of CC vs. AZ with respect to improvement in T levels in HIM. METHODS: We randomized 26 HIM (T less than 350 ng/dL and normal luteinizing hormone [LH]). Patients were randomized to CC (25 mg/day) or AZ (1 mg/day) for 12 weeks. Hormones assayed were total T, free T, E2, LH, follicle stimulating hormone (FSH), and sex hormone binding globulin (SHBG). Patient-reported outcomes were the International Index of Erectile Function, Erection Hardness Scale, and the Androgen Deficiency in the Aging Male questionnaires. Blood tests and questionnaires were recorded at baseline, 6 and 12 weeks. Semen analyses were performed at baseline and 12 weeks. RESULTS: T increased significantly from baseline in both groups at 6 and 12 weeks. There was a significantly larger increase in T and mean increase from baseline in CC vs. AZ (571 vs. 408 ng/dL, respectively). Whereas E-2 levels increased in the CC group, they decreased in the AZ group. Though both groups demonstrated an increase in T-to-E-2 ratio from baseline, statistic significance at 6 and 12 weeks was only achieved with AZ. Neither group demonstrated significant changes in seminal parameters or patient-reported outcomes. CONCLUSIONS: We failed to demonstrate equivalence of CC vs. AZ. [B]CC resulted in significantly higher T levels than AZ. AZ resulted in a significantly larger increase in T/E-2 ratio than CC. No significant differences between CC and AZ on seminal parameters.[/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Clomiphene versus Anastrozole for Testosterone Boosting: A study
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