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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Clomiphene to Natesto results
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<blockquote data-quote="madman" data-source="post: 203545" data-attributes="member: 13851"><p>For monotherapy, once-daily dosing would not suffice!</p><p></p><p><strong>post #22</strong></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/anyone-tried-testosterone-base-no-ester.21521/page-2[/URL]</p><p></p><p></p><p><strong><em>But is there something special about doing it three times with the nasal gel? Maybe in the Natesto product development phase, they experimented with different frequencies?</em></strong></p><p></p><p>I think with multiple peaks (2-3x daily) it would more effective and you would reap the overall beneficial effects regarding (energy/mood/libido/erectile function/body composition).</p><p></p><p>They state that testosterone levels or symptoms are used to guide titration decisions between either twice daily or three times a day doses used to restore testosterone levels to the normal range.</p><p></p><p>If dosing once daily was truly optimal there would be no need for 2-3 times/day application</p><p></p><p></p><p><strong><em>*Based on the data, Acerus believes that the mechanism of action of NATESTO® is unique whereby the peaks in testosterone generated by NATESTO® dosing provide efficacy and improvement of symptoms, while the time between doses (4-8 hours) allows for the maintenance of testicular testosterone production and sperm production.</em></strong></p><p></p><p><em><strong>*The 24-hour pharmacokinetic profile of testosterone for patients on TNG treatment has two or three discrete peaks (“pulses”) of testosterone provoked by LH secretions that occur on average every 2 hours. A maximal peak of testosterone appears at about 1h (Tmax) followed by a return to endogenous, pre-dose levels, 4-6 hours later (t1/2 ~1h).</strong></em></p><p></p><p><strong><em>*Natesto, a testosterone-based nasal gel, is self-administered three times per day. Approximately 40 minutes after administration, testosterone levels return to normal, although Natesto’s half-life is widely variable, between 10 and 100 minutes.</em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 203545, member: 13851"] For monotherapy, once-daily dosing would not suffice! [B]post #22[/B] [URL unfurl="true"]https://www.excelmale.com/forum/threads/anyone-tried-testosterone-base-no-ester.21521/page-2[/URL] [B][I]But is there something special about doing it three times with the nasal gel? Maybe in the Natesto product development phase, they experimented with different frequencies?[/I][/B] I think with multiple peaks (2-3x daily) it would more effective and you would reap the overall beneficial effects regarding (energy/mood/libido/erectile function/body composition). They state that testosterone levels or symptoms are used to guide titration decisions between either twice daily or three times a day doses used to restore testosterone levels to the normal range. If dosing once daily was truly optimal there would be no need for 2-3 times/day application [B][I]*Based on the data, Acerus believes that the mechanism of action of NATESTO® is unique whereby the peaks in testosterone generated by NATESTO® dosing provide efficacy and improvement of symptoms, while the time between doses (4-8 hours) allows for the maintenance of testicular testosterone production and sperm production.[/I][/B] [I][B]*The 24-hour pharmacokinetic profile of testosterone for patients on TNG treatment has two or three discrete peaks (“pulses”) of testosterone provoked by LH secretions that occur on average every 2 hours. A maximal peak of testosterone appears at about 1h (Tmax) followed by a return to endogenous, pre-dose levels, 4-6 hours later (t1/2 ~1h).[/B][/I] [B][I]*Natesto, a testosterone-based nasal gel, is self-administered three times per day. Approximately 40 minutes after administration, testosterone levels return to normal, although Natesto’s half-life is widely variable, between 10 and 100 minutes.[/I][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Clomiphene to Natesto results
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