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All men were initiated on Natesto 11 mg twice daily intranasal administration, and if they did not achieve eugonadal levels obtained 1 hour after administration of Natesto 1 month after initiation of treatment, the dose was titrated up to 3 times daily. Only 6/41 (14.6%) of the men required up-titration to three times daily dosing. The results reported on Natesto were on the treatment regimen that achieved eugonadal levels.