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Mental Health
Clomiphene and Anxiety / Negative Thoughts
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<blockquote data-quote="Kirk001" data-source="post: 117638" data-attributes="member: 18401"><p>Well, I did 30 days on clomiphene and then stopped to transition to TRT. I got labs done a little early, on day 21, because by then I was almost certain I wanted to discontinue taking it. </p><p></p><p>Total Testosterone went from 297 pre-treatment to 959 at day 21. Assuming this rate of increase continued to day 30, it would have been around 1243 (estimated) by steady state at day 30. </p><p></p><p>Estradiol, Sensitive went from 14.5 pre-treatment to 23.6 at day 21. Assuming this rate of increase continued to day 30, it would have been around 27.5 (estimated) by steady state at day 30.</p><p></p><p>Despite the improvement of the numbers, I felt no positive effects from this medication, only negatives. It increased anxiety and put me in a pessimistic mood. My appetite increased and I found it harder to stay under my daily calorie goal, so I ate too much and my body fat % increased. </p><p></p><p>And as a nice little parting gift, on my last day of taking it, I awoke to symptoms that I assume were the beginning stages of gynecomastia. (I posted another thread about this... burning nipples, pecs feeling sore/swollen, pea-sized lump by my right nipple, etc.) </p><p></p><p>So I am glad to be done with this and I'm hoping that TRT will be different. Moving forward it would seem that I may be particularly sensitive to estrogen and will need to keep it relatively low. Either that or I was particularly sensitive to the estrogen agonist part of the medication.</p></blockquote><p></p>
[QUOTE="Kirk001, post: 117638, member: 18401"] Well, I did 30 days on clomiphene and then stopped to transition to TRT. I got labs done a little early, on day 21, because by then I was almost certain I wanted to discontinue taking it. Total Testosterone went from 297 pre-treatment to 959 at day 21. Assuming this rate of increase continued to day 30, it would have been around 1243 (estimated) by steady state at day 30. Estradiol, Sensitive went from 14.5 pre-treatment to 23.6 at day 21. Assuming this rate of increase continued to day 30, it would have been around 27.5 (estimated) by steady state at day 30. Despite the improvement of the numbers, I felt no positive effects from this medication, only negatives. It increased anxiety and put me in a pessimistic mood. My appetite increased and I found it harder to stay under my daily calorie goal, so I ate too much and my body fat % increased. And as a nice little parting gift, on my last day of taking it, I awoke to symptoms that I assume were the beginning stages of gynecomastia. (I posted another thread about this... burning nipples, pecs feeling sore/swollen, pea-sized lump by my right nipple, etc.) So I am glad to be done with this and I'm hoping that TRT will be different. Moving forward it would seem that I may be particularly sensitive to estrogen and will need to keep it relatively low. Either that or I was particularly sensitive to the estrogen agonist part of the medication. [/QUOTE]
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Clomiphene and Anxiety / Negative Thoughts
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