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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Clomid & Testosterone: Why they don't work together - By Mike Gaiso
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<blockquote data-quote="Cataceous" data-source="post: 163020" data-attributes="member: 38109"><p><span style="font-size: 15px"></span></p><p><span style="font-size: 15px">I</span>nteresting information. If I'm remembering correctly, there is some evidence that testosterone has a suppressive effect independent of the conversion to estradiol. A little tangential, but I'm wondering if DHT derivatives, e.g. mesterolone (Proviron) or drostanolone (Masteron), produce this metabolite?</p><p></p><p><span style="font-size: 15px">Some other tidbits from the </span><a href="https://en.wikipedia.org/wiki/3β-Androstanediol" target="_blank"><span style="font-size: 15px">Wiki article</span></a><span style="font-size: 15px">: <span style="color: rgb(34, 34, 34)">3β-androstanediol is described as an estrogen, which seems odd given that DHT itself is not considered estrogenic in any respect. <span style="font-size: 15px"><span style="color: rgb(34, 34, 34)">3β-androstanediol is </span></span>also formed via 5α-reduction of DHEA, so if you're low in the <span style="font-size: 15px"><span style="color: rgb(34, 34, 34)">5α-reductase enzymes then there's a double-whammy reducing this metabolite. It has some nice effects: "Through the ERβ, 3β-diol positively regulates oxytocin neurons and signaling in the paraventricular nucleus of hypothalamus (PVN), and has been found to have antidepressant, anxiolytic, cognitive-enhancing, and stress-relieving effects via this action."</span></span></span></span></p><p></p><p><span style="font-size: 15px"><span style="color: rgb(34, 34, 34)"><span style="font-size: 15px"><span style="color: rgb(34, 34, 34)">Normal levels in men are 239 ± 76 pg/ml, around ten times the level of estradiol. This seems significant because <span style="font-size: 15px"><span style="color: rgb(34, 34, 34)">3β-androstanediol "has approximately 3% and 7% of the affinity of estradiol at the ERα and ERβ, respectively." Would it be correct to say then that this metabolite has almost equal influence on <span style="font-size: 15px"><span style="color: rgb(34, 34, 34)"><span style="font-size: 15px"><span style="color: rgb(34, 34, 34)"><span style="font-size: 15px"><span style="color: rgb(34, 34, 34)">ERβ compared to estradiol?</span></span></span></span></span></span></span></span></span></span></span></span></p></blockquote><p></p>
[QUOTE="Cataceous, post: 163020, member: 38109"] [SIZE=15px] I[/SIZE]nteresting information. If I'm remembering correctly, there is some evidence that testosterone has a suppressive effect independent of the conversion to estradiol. A little tangential, but I'm wondering if DHT derivatives, e.g. mesterolone (Proviron) or drostanolone (Masteron), produce this metabolite? [SIZE=15px]Some other tidbits from the [/SIZE][URL='https://en.wikipedia.org/wiki/3β-Androstanediol'][SIZE=15px]Wiki article[/SIZE][/URL][SIZE=15px]: [COLOR=rgb(34, 34, 34)]3β-androstanediol is described as an estrogen, which seems odd given that DHT itself is not considered estrogenic in any respect. [SIZE=15px][COLOR=rgb(34, 34, 34)]3β-androstanediol is [/COLOR][/SIZE]also formed via 5α-reduction of DHEA, so if you're low in the [SIZE=15px][COLOR=rgb(34, 34, 34)]5α-reductase enzymes then there's a double-whammy reducing this metabolite. It has some nice effects: "Through the ERβ, 3β-diol positively regulates oxytocin neurons and signaling in the paraventricular nucleus of hypothalamus (PVN), and has been found to have antidepressant, anxiolytic, cognitive-enhancing, and stress-relieving effects via this action."[/COLOR][/SIZE][/COLOR][/SIZE] [SIZE=15px][COLOR=rgb(34, 34, 34)][SIZE=15px][COLOR=rgb(34, 34, 34)]Normal levels in men are 239 ± 76 pg/ml, around ten times the level of estradiol. This seems significant because [SIZE=15px][COLOR=rgb(34, 34, 34)]3β-androstanediol "has approximately 3% and 7% of the affinity of estradiol at the ERα and ERβ, respectively." Would it be correct to say then that this metabolite has almost equal influence on [SIZE=15px][COLOR=rgb(34, 34, 34)][SIZE=15px][COLOR=rgb(34, 34, 34)][SIZE=15px][COLOR=rgb(34, 34, 34)]ERβ compared to estradiol?[/COLOR][/SIZE][/COLOR][/SIZE][/COLOR][/SIZE][/COLOR][/SIZE][/COLOR][/SIZE][/COLOR][/SIZE] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Clomid & Testosterone: Why they don't work together - By Mike Gaiso
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