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I've had sore joints since I began TRT back in may and my E2 was usually above range most of the time, so it doesn't necessarily mean your E2 is low. I've heard that anastrozole can mess with your cholesterol levels, so perhaps lower your test dosage which will allow you to reduce your AI dosage. Also Dr Crisler mentioned when a guys T levels are too high it can mess with your lipids. Some guys report HCG working in the beginning but starts to become less effective over time, either increase or decrease dosage or perhaps inject more often.