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There have been some pretty credible reports like this. The more I think about clomiphene in particular, the less surprised I am about its low success rate. With it one is taking a pretty strong estrogen—zuclomiphene—combined with a strong anti-estrogen—enclomiphene. These have different relative strengths at different estrogen receptors. In addition there's usually more estradiol created due to both the higher LH and the higher endogenous testosterone. With all this jumbled together, how likely is it to achieve a reasonable balance of androgenicity and estrogenicity in the tissues that matter?