ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Clomid causes less polycythemia than TRT
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Nelson Vergel" data-source="post: 50003" data-attributes="member: 3"><p><strong>CLOMIPHENE CITRATE RESULTS IN A SIGNIFICANTLY LOWER INCIDENCE OF POLYCYTHEMIA COMPARED TO EXOGENOUS TESTOSTERONE REPLACEMENT IN HYPOGONADAL MEN.</strong></p><p></p><p></p><p></p><p>INTRODUCTION AND OBJECTIVES</p><p>It is established that exogenous testosterone replacement therapy (TRT) may be detrimental to a man's fertility. Clomiphene citrate (CC) is commonly used, off-label, to treat hypogonadal men in a fertility preserving manner. Polycythemia is a concerning side effect of direct TRT, however, there is no data regarding CC and polycythemia risk.</p><p></p><p>METHODS</p><p>The incidence of polycythemia was retrospectively assessed in men diagnosed with hypogonadism and treated with CC versus TRT at different institutions between 3/2011 - 4/2015. Polycythemia was defined as a hematocrit > 52%.</p><p></p><p>RESULTS</p><p>A total of 188 CC- and 175 TRT-treated men were included. CC treated men were younger (38 vs 51.5 years of age). TRT treated men had longer treatment durations than CC treated men, 19.6 months vs 9.2 months respectively. The incidence of polycythemia in men receiving CC was 1.7% versus 11.2% in men on TRT (p=0.0003). This significance remained after correction for age, site, smoking history, and pre-treatment hematocrit via logarithmic regression. The mean changes in Hct were 3.0% and 0.6%, and the mean changes in serum testosterone (T) were 333.1 ng/dL and 367.6 ng/dL in TRT-treated and CC-treated men, respectively.</p><p></p><p>CONCLUSIONS</p><p>The incidence of polycythemia in men treated with CC is markedly lower than that of TRT treated men. The improvement in absolute serum T levels was similar to TRT treated men. There is not a significant risk of polycythemia in men treated with CC for hypogonadism.</p><p></p><p>Source of Funding: None</p><p></p><p>The Journal of Urology</p><p>Volume 195, Issue 4, Supplement, April 2016, Pages e1007</p><p></p><p>2016 Annual Meeting Program Abstracts</p><p></p><p>AUA Annual Meeting</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 50003, member: 3"] [b]CLOMIPHENE CITRATE RESULTS IN A SIGNIFICANTLY LOWER INCIDENCE OF POLYCYTHEMIA COMPARED TO EXOGENOUS TESTOSTERONE REPLACEMENT IN HYPOGONADAL MEN.[/b] INTRODUCTION AND OBJECTIVES It is established that exogenous testosterone replacement therapy (TRT) may be detrimental to a man's fertility. Clomiphene citrate (CC) is commonly used, off-label, to treat hypogonadal men in a fertility preserving manner. Polycythemia is a concerning side effect of direct TRT, however, there is no data regarding CC and polycythemia risk. METHODS The incidence of polycythemia was retrospectively assessed in men diagnosed with hypogonadism and treated with CC versus TRT at different institutions between 3/2011 - 4/2015. Polycythemia was defined as a hematocrit > 52%. RESULTS A total of 188 CC- and 175 TRT-treated men were included. CC treated men were younger (38 vs 51.5 years of age). TRT treated men had longer treatment durations than CC treated men, 19.6 months vs 9.2 months respectively. The incidence of polycythemia in men receiving CC was 1.7% versus 11.2% in men on TRT (p=0.0003). This significance remained after correction for age, site, smoking history, and pre-treatment hematocrit via logarithmic regression. The mean changes in Hct were 3.0% and 0.6%, and the mean changes in serum testosterone (T) were 333.1 ng/dL and 367.6 ng/dL in TRT-treated and CC-treated men, respectively. CONCLUSIONS The incidence of polycythemia in men treated with CC is markedly lower than that of TRT treated men. The improvement in absolute serum T levels was similar to TRT treated men. There is not a significant risk of polycythemia in men treated with CC for hypogonadism. Source of Funding: None The Journal of Urology Volume 195, Issue 4, Supplement, April 2016, Pages e1007 2016 Annual Meeting Program Abstracts AUA Annual Meeting [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Clomid causes less polycythemia than TRT
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top