ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Clomid and Steroidogenesis
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="madman" data-source="post: 216314" data-attributes="member: 13851"><p><strong><em>*Steroidogenesic pathways, carried on by the enzyme sets belonging to both adrenal and gonadal glands [20, 21], might help in <u>highlighting which gland is the main CC target</u></em></strong></p><p></p><p></p><p></p><p></p><p><em><strong>In conclusion, in previous work, we showed that CC treatment improves the function of the HPG axis in obese dysmetabolic men with functional hypogonadism by increasing serum LH and, in turn, T and E2 [5]. <u>In the present study, we found that the improvement in T secretion due to CC seems to be caused by the testicular Δ5 rather than the Δ4 pathway, without causing a significant increase in 5α-reductase activity at the target tissues</u>. In addition, we showed that there is an <u>enhancement of plasma F levels, but not of the free-F, indicating a lack of a direct effect of CC therapy on the adrenal gland</u>.</strong></em></p><p><em><strong></strong></em></p><p><em><strong>Future studies are needed to <u>establish whether these hormonal changes induced by CC remain or progress during longer treatment periods, which could counter the evident beneficial effects of CC treatment on testicular steroidogenesis</u>.</strong></em></p><p></p><p></p><p></p><p></p><p><strong>▶Fig. 1 <u>Steroids pathway</u>. Steroids pathway increased under CC is shown with bold arrows. Only significant fold changes are reported next to the arrow (refer to ▶Table 4 for all the steroids fold changes). n. a. (fold changes not available).</strong></p><p><strong>[ATTACH=full]19314[/ATTACH]</strong></p></blockquote><p></p>
[QUOTE="madman, post: 216314, member: 13851"] [B][I]*Steroidogenesic pathways, carried on by the enzyme sets belonging to both adrenal and gonadal glands [20, 21], might help in [U]highlighting which gland is the main CC target[/U][/I][/B] [I][B]In conclusion, in previous work, we showed that CC treatment improves the function of the HPG axis in obese dysmetabolic men with functional hypogonadism by increasing serum LH and, in turn, T and E2 [5]. [U]In the present study, we found that the improvement in T secretion due to CC seems to be caused by the testicular Δ5 rather than the Δ4 pathway, without causing a significant increase in 5α-reductase activity at the target tissues[/U]. In addition, we showed that there is an [U]enhancement of plasma F levels, but not of the free-F, indicating a lack of a direct effect of CC therapy on the adrenal gland[/U]. Future studies are needed to [U]establish whether these hormonal changes induced by CC remain or progress during longer treatment periods, which could counter the evident beneficial effects of CC treatment on testicular steroidogenesis[/U].[/B][/I] [B]▶Fig. 1 [U]Steroids pathway[/U]. Steroids pathway increased under CC is shown with bold arrows. Only significant fold changes are reported next to the arrow (refer to ▶Table 4 for all the steroids fold changes). n. a. (fold changes not available). [ATTACH type="full"]19314[/ATTACH][/B] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Clomid and Steroidogenesis
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top