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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Clinical studies on low intensity extracorporeal shockwave therapy for erectile dysfunction: a systematic review and meta-analysis of randomised
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<blockquote data-quote="madman" data-source="post: 135927" data-attributes="member: 13851"><p><strong>Clinical studies on low intensity extracorporeal shockwave therapy for erectile dysfunction: a systematic review and meta-analysis of randomised controlled trials</strong></p><p></p><p></p><p></p><p></p><p></p><p><strong><span style="color: rgb(184, 49, 47)">Abstract</span></strong> </p><p>The efficacy of low intensity extracorporeal shock wave therapy (LI-ESWT) for erectile dysfunction (ED) has received hard criticism and recently published meta-analyses were not able to provide further insights, nor specific recommendations. The aim of this systematic review and meta-analysis is to evaluate the efficacy of LI-ESWT for ED, identify the ideal treatment population and treatment protocol, and provide recommendations for future research in the field. A systematic research for relevant clinical studies published from January 2010 to September 2018 was performed, using the following databases: Medline, Embase, The Cochrane Library, Scopus, and Web of Science. Only clinical studies that investigated the efficacy of LI-ESWT for ED only, and reported primary outcomes using IIEF-EF scores/questionnaires were included. Both, randomised controlled trials (RCTs) and cohort studies were included, but the meta-analysis was performed only for sham controlled RCTs. Ten RCTs including 873 patients were selected for the meta-analysis. Pooling data of these studies showed that LI-ESWT could significantly improve erectile function in men with ED regarding both patient-subjective outcomes (IIEF-EF: +3.97; 95% CI [2.09–5.84]; p<0.0001, EHS≥3: OR: 4.35; 95% CI [1.82–10.37]; p=0.0009) and patient objective outcomes (peak systolic velocity: +4.12; 95% CI [2.30–5.94]; p<0.00001). In conclusion, the present meta analysis provided results showing that LI-ESWT significantly improves erectile function in patients with vasculogenic ED.</p><p></p><p></p><p></p><p></p><p></p><p>In conclusion, <strong><span style="color: rgb(184, 49, 47)">the present meta-analysis showed that LIESWT significantly improves erectile function in patients with vasculogenic ED.</span></strong> <strong>Larger multicentric RCTs with longer than 1-year follow-up are needed, before considering this new treatment as the new standard for the treatment of ED. </strong>However, LI-ESWT could be offered to patients with vasculogenic ED (especially to PDE5i-responders) as an alternative first-line treatment, especially in younger patients searching for a non-pharmacological treatment.</p></blockquote><p></p>
[QUOTE="madman, post: 135927, member: 13851"] [B]Clinical studies on low intensity extracorporeal shockwave therapy for erectile dysfunction: a systematic review and meta-analysis of randomised controlled trials[/B] [B][COLOR=rgb(184, 49, 47)]Abstract[/COLOR][/B] The efficacy of low intensity extracorporeal shock wave therapy (LI-ESWT) for erectile dysfunction (ED) has received hard criticism and recently published meta-analyses were not able to provide further insights, nor specific recommendations. The aim of this systematic review and meta-analysis is to evaluate the efficacy of LI-ESWT for ED, identify the ideal treatment population and treatment protocol, and provide recommendations for future research in the field. A systematic research for relevant clinical studies published from January 2010 to September 2018 was performed, using the following databases: Medline, Embase, The Cochrane Library, Scopus, and Web of Science. Only clinical studies that investigated the efficacy of LI-ESWT for ED only, and reported primary outcomes using IIEF-EF scores/questionnaires were included. Both, randomised controlled trials (RCTs) and cohort studies were included, but the meta-analysis was performed only for sham controlled RCTs. Ten RCTs including 873 patients were selected for the meta-analysis. Pooling data of these studies showed that LI-ESWT could significantly improve erectile function in men with ED regarding both patient-subjective outcomes (IIEF-EF: +3.97; 95% CI [2.09–5.84]; p<0.0001, EHS≥3: OR: 4.35; 95% CI [1.82–10.37]; p=0.0009) and patient objective outcomes (peak systolic velocity: +4.12; 95% CI [2.30–5.94]; p<0.00001). In conclusion, the present meta analysis provided results showing that LI-ESWT significantly improves erectile function in patients with vasculogenic ED. In conclusion, [B][COLOR=rgb(184, 49, 47)]the present meta-analysis showed that LIESWT significantly improves erectile function in patients with vasculogenic ED.[/COLOR][/B] [B]Larger multicentric RCTs with longer than 1-year follow-up are needed, before considering this new treatment as the new standard for the treatment of ED. [/B]However, LI-ESWT could be offered to patients with vasculogenic ED (especially to PDE5i-responders) as an alternative first-line treatment, especially in younger patients searching for a non-pharmacological treatment. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Clinical studies on low intensity extracorporeal shockwave therapy for erectile dysfunction: a systematic review and meta-analysis of randomised
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